Role of Endogenous Angiotensin II in Renal Hemodynamic and Excretory Responses to L-Arginine Infusion

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The purpose of this study was to investigate whether endogenous angiotensin II has a functional role in renal hemodynamic and excretory changes induced by L-arginine, a substrate for nitric oxide (NO), in anesthetized rats. During the intravenous infusion of L-arginine (50,100,200 μmol/kg・min), there was no significant change in systemic or renal hemodynamics, but urine flow and urinary sodium excretion markedly increased in a dose-dependent manner. Simultaneously, L-arginine infusion produced an increase in urinary excretion of NO metabolites, No^-_2 and NO^-_3. Treatment with L-158809 {5,7-dimethyl-2-ethyl-3-[[2'-(1H-tetrazol-5-yl)[1,1']-biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine} (0.3 mg/kg), a selective angiotensin II type I receptor antagonist, caused a reduction in mean arterial pressure, and a rise in renal blood flow and glomerular filtration rate, with no changes in excretory responses. In the presence of L-158809,L-arginine-induced diuretic and natriuretic actions were observed to the same extent as seen in the absence of L-158809. These data suggest that the infusion of L-arginine causes diuresis and natriuresis, possibly via the formation of nitric oxide in the kidney, and that endogenous angiotensin II is not involved in the L-arginine-induced renal actions.
公益社団法人日本薬学会の論文
1996-09-15