Tempol Protects against Ischemic Acute Renal Failure by Inhibiting Renal Noradrenaline Overflow and Endothelin-1 Overproduction(Pharmacology)
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概要
- 論文の詳細を見る
The effects of tempol, a superoxide dismutase mimetic, on ischemia/reperfusion-induced acute renal failure (ARF), noradrenaline (NA) overflow and endothelin-1 (ET-1) overproduction in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood urea nitrogen, plasma creatinine concentration, and fractional excretion of sodium, NA concentrations in renal venous plasma, and renal ET-1 contents were determined. Renal function in ARF rats markedly decreased at 1 d after reperfusion. Pre-ischemic treatment with tempol (10,100 mg/kg, i.v.) dose-dependently attenuated the ischemia/reperfusion-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damages, such as tubular necrosis, proteinaceous casts in tubuli and medullary congestion, which were also significantly suppressed by the tempol treatment. There was a significant increase in NA concentrations in renal venous plasma after the ischemia/reperfusion, and this increase was markedly suppressed by the treatment with tempol. In addition, tempol treatment significantly attenuated the increment of ET-1 content in the kidney exposed to the ischemia/reperfusion. These findings suggest that tempol improves the post-ischemic renal injury by inhibiting the neural activity of renal sympathetic nerve and ET-1 overproduction.
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
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MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
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Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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Okabe Makoto
Third Division Department Of Internal Medicine Osaka Medical College
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OHKITA Mamoru
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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FUJII Toshihide
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Okabe Makoto
The Third Division Internal Medicine Osaka College
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Fujii Toshihide
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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