Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia(Experimental Investigation)
スポンサーリンク
概要
- 論文の詳細を見る
Background Hypoxia caused by sleep apnea might be associated with an increased risk of cardiovascular events in subjects with metabolic syndrome. The aim of this study was to examine the effect of hypoxia on the left ventricular (LV) myocardium and evaluate the cardioprotective effect of an angiotensin-II receptor blocker (ARB) in diabetic rats. Methods and Results Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 30 weeks of age (n=30) were divided into 2 groups that were treated with vehicle or candesartan 0.2mg・kg^<-1>・day^<-1>. The animals were housed in a hypoxic gas chamber (oxygen, 10.0±0.5%, mean±standard deviation) for 2 weeks. Hypoxia increased right ventricular (RV) systolic pressure (hypoxia; 78±14mmHg vs control; 22±5, p<0.05), but did not increase LV systolic pressure (131±23mmHg vs 121±10). Hypoxia exacerbated the degeneration of cardiomyocytes, and accelerated the expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the myocardium. Treatment with ARB decreased RV and LV pressures (46±7 and 100±18mmHg, respectively), suppressed the expression of HIF-1α and VEGF, and preserved the fine structure of the LV myocardium. Conclusions ARB exhibited cardioprotection under hypoxia, in part through the reduction of blood pressure and cytokine expression, in OLETF rats. Thus, ARB might be a potent agent for the treatment of diabetic patients with the complication of sleep apnea.
- 社団法人日本循環器学会の論文
- 2006-05-20
著者
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SOHMIYA Koichi
Third Department of Internal Medicine, Osaka Medical College
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Okuda Nobuaki
Third Department of Internal Medicine, Osaka Medical College
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Hayashi Tetsuya
Third Department of Internal Medicine, Osaka Medical College
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Mori Tatsuhiko
Third Department of Medicine, Osaka Medical College
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MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Okuda Nobuaki
The Third Department Of Internal Medicine Osaka Medical College
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Hayashi T
Third Dep. Of Medicine Osaka Medical Coll. Jpn
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Hayashi Tetsuya
大阪医科大学 薬理学教室
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Kudoh Sumiyo
Department Of Internal Medicine Iii Osaka Medical College
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Sohmiya Koichi
Department Of Internal Medicine Iii Osaka Medical College
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Sohmiya Koichi
Third Department Of Internal Medicine Osaka Medical College
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Kitaura Yasushi
Third Department Of Internal Medicine Osaka Medical College
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INAMOTO Sakiko
Department of Internal Medicine III, Osaka Medical College
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YAMASHITA Chika
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
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Inamoto Sakiko
Department Of Internal Medicine Iii Osaka Medical College
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Inamoto Sakiko
Third Department Of Internal Medicine Osaka Medical College
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Tazawa Naoko
Osaka University of Pharmaceutical Sciences Osaka Medical College
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Yamashita Chika
Osaka University of Pharmaceutical Sciences Osaka Medical College
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Nakano Daisuke
Osaka University of Pharmaceutical Sciences Osaka Medical College
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Matsumura Yasuo
Osaka University of Pharmaceutical Sciences Osaka Medical College
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Sakai Akiko
Department of Chemistry, Osaka Medical College
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Furuya Eisuke
Department of Chemistry, Osaka Medical College
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Yamada K
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Hayashi Tetsuya
Third Department Of Medicine Osaka Medical College
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Matsumura Yasuo
Osaka University Of Pharmaceutical Sciences
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Yamashita Chika
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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Mori Tatsuhiko
Department Of Internal Medicine Iii Osaka Medical College
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Tazawa Naoko
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Furuya Eisuke
Department Of Chemistry Osaka Medical College
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Nakano Daisuke
Osaka University Of Pharmaceutical Sciences
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Mori Tatsuhiko
Third Department Of Medicine Osaka Medical College
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Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Okuda Nobuaki
Third Department Of Internal Medicine Osaka Medical College
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Hayashi Tetsuya
Third Department Of Internal Medicine Osaka Medical College
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Hanafusa Toshiaki
Third Department Of Medicine Osaka Medical College
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Tanaka Hidekazu
Third Department Of Medicine Osaka Medical College
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Yoshikawa Katsuhiro
Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Sakai Akiko
Department Of Chemistry Osaka Medical College
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Sakai Akiko
Department Of Animal Science Obihiro University Of Agriculture And Veterinary Medicine
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Mori Tatsuhiko
Department Of Gastroenterology And Neurology Faculty Of Medicine Kagawa University
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Mori Tatsuhiko
Third Department of Internal Medicine, Osaka Medical College
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