Myocardial Inflammatory Cell Infiltrates in Cases of Dilated Cardiomyopathy as a Determinant of Outcome Following Partial Left Ventriculectomy
スポンサーリンク
概要
- 論文の詳細を見る
Partial left ventriculectomy(PLV)can be used to treat refractory congestive heart failure caused by dilated cardiomyopathy(DCM). In order to understand the relationship between the underlying myocardial injury and early clinical outcomes after PLV, histopathologic, immunohistochemical and virologic studies of the resected myocardium were performed. The posterolateral left ventricular walls from 27 patients with idiopathic DCM were examined. Cardiomyocyte diameter, degree of myocardial fibrosis, degree of cardiomyocyte degeneration, and degree of inflammatory cell infiltration were compated with mortality rates. Polymerase chain reaction was performed to detect enterovirus genome in the myocardium. Some patients had inflammatory cell infiltrates with focal accumulations of lymphocytes and macrophages, including both cytotoxic/suppressor T-cells and helper/inducer T-cells. The number of inflammatory cells(activated lymphocytes plus macrophages/mm^2)was significantly greater in patients who died of cardiac insufficiency after surgery(27.8±5.7 ; n=7)than in the survivors(11.1±2.5 ; n=15). There was no significant difference in the degree of myocardial fibrosis, cardiomyocyte diameter or degree of cardiomyocyte degeneration between the 2 groups. Enterovirus genome was detected in the myocardium of 9(38%)of 24 patients examined and 5 of these enterovirus-positive hearts had severe inflammatory cell infiltrates(37.9±2.5/mm^2). Early survival in patients undergoing PLV for DCM is significantly affected by the degree of myocardial inflammation, so patients with more severe or ongoing inflammation may have poor clinical outcomes. Chronic myocarditis may play an important role in the etiology and pathophysiology of idiopathic DCM.
- 社団法人日本循環器学会の論文
- 2001-08-20
著者
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Sawada Hitoshi
The Cardiovascular Institute
-
Kitaura Yasushi
The Third Division, Department of Internal Medicine
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Terasaki F
大阪医科大学 第三内科
-
SUMA Hisayoshi
The Cardiovascular Institute
-
Hayashi T
Third Dep. Of Medicine Osaka Medical Coll. Jpn
-
Hayashi Tetsuya
大阪医科大学 薬理学教室
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ISOMURA Tadashi
Hayama Heart Center
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Fujioka Shigekazu
Third Division Department Of Internal Medicine Osaka Medical College
-
Kawamura K
Department Of Internal Medicine (iii) Osaka Medical College
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Kawamura Keishiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
The Third Division Internal Medicine Osaka College
-
Kawamura Keishiro
The Third Divisin Department Of Internal Medicine Osaka Medical College
-
Terasaki Fumio
The Third Department of Internal Medicine, Osaka Medical College
-
Shimomura Hiroaki
The Third Division, Department of Internal Medicine, Osaka Medical College
-
Kanzaki Yumiko
Third Department Of Internal Medicine Osaka Medical College
-
Terasaki Fumio
The Third Department Of Internal Medicine Osaka Medical College
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Terasaki Fumio
The Third Division Department Of Internal Medicine Osaka Medical College
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OKABE MAKOTO
The Thiird Department of Internal Medicine, Osaka Medical College
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Kawamura Keishiro
Department Of Internal Medicine (iii) Osaka Medical College
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Fujioka Shigekazu
The Third Division, Department of Internal Medicine, Osaka Medical College
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Isomura Tadashi
Division of Cardiovascular Surgery, Hayama Heart Center
-
Suma Hisayoshi
Division of Cardiovascular Surgery, Hayama Heart Center
-
Kanzaki Yumiko
The Third Division, Department of Internal Medicine, Osaka Medical College
-
Hayshi Tetsuya
The Third Division, Department of Internal Medicine, Osaka Medical College
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Toko Haruhiro
The Third Division, Department of Internal Medicine, Osaka Medical College
-
Horii Yasuhiro
Division of Cardiovascular Surgery, Hayama Heart Center
-
Toko Haruhiro
Third Department of Internal Medicine
-
Toukou Haruhiro
Third Division Department Of Internal Medicine Osaka Medical College
-
Shimomura Hiroaki
The Third Division Department Of Internal Medicine Osaka Medical College
-
Yoshida Kentaro
Depatment Of Pediatrics Institute Of Clinical Medicine University Of Tsukuba
-
Okabe Makoto
Third Division Department Of Internal Medicine Osaka Medical College
-
Yoshida Kentaro
Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
-
Horii Yasuhiro
Division Of Cardiovascular Surgery Hayama Heart Center
-
Isomura Tadashi
Division Of Cardiovascular Surgery Hayama Heart Center
-
Okabe Makoto
The Third Division Internal Medicine Osaka College
-
Kitaura Yasushi
The Third Department Of Internal Medicine Osaka Medical College
-
Hayashi Tetsuya
Third Department Of Internal Medicine Osaka Medical College
-
Hanafusa Toshiaki
Third Department Of Medicine Osaka Medical College
-
Okabe Makoto
Third Department Of Medicine Osaka Medical College
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Kawamura Keishiro
3rd Div. Dept. Intern. Med. Osaka Medical College
-
Kawamura Keishiro
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
-
Kawamura Keishiro
The 3rd Div. Dept.of Int.med. Osaka Medical College
-
Kawamura Keishiro
The Third Department Of Internal Medicine Osaka Medical College
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Katayama Kazuhiro
2nd Dept. Of Internal Med. Yamaguchi University
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