Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of dietary supplementation of L-carnosine (β-alanyl-_L -histidine) on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood urea nitrogen, plasma creatinine, creatinine clearance, urine flow, urinary osmolality and fractional excretion of sodium were measured. Renal function in ARF rats markedly decreased at 1 d after reperfusion. Prior feeding of _L-carnosine-containing diet (0.0001 w/w%) for 2 weeks attenuated the ischemia/reperfusion-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damages, such as tubular necrosis, proteinaceous casts in tubuli and medullary congestion, which were also significantly suppressed by the dietary supplementation of _L-carnosine. These findings strongly suggest that _L-carnosine supplementation is useful as a prophylactic treatment in the development of the ischemic ARF.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
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MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
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MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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Tsuruoka N
Laboratory For Health Care Science Research Center Suntory Ltd.
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
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Tanaka T
Institute For Health Care Science Suntory Ltd.
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Tanaka Takaharu
Institute For Health Care Science Suntory Ltd.
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Tanaka T
Suntory Consumer Health Products Division
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
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Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
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Tsuruoka Nobuo
Institute for Health Care Science, Research Center, Suntory Ltd.
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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FUJII Toshihide
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Fujii Toshihide
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Tsuruoka Nobuo
Institute For Health Care Science Suntory Limited
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Tanaka Takaharu
Institute For Fundamental Research Suntory Ltd.
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Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Tanaka Takaharu
Institute For Biomedical Research Suntory Ltd.
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