STIMULANT EFFECTS OF W-7,A CALMODULIN-ANTAGONIST, ON RENIN RELEASE FROM RAT KIDNEY CORTICAL SLICES
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概要
- 論文の詳細を見る
Effect of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin-antagonist, on renin release was examined using rat kidney cortical slices. Although the amounts of renin release from the slices were stable during incubation of 3 consecutive 15 min periods in Krebs-Ringer bicarbonate solution (pH 7.4), the addition of W-7 to the incubation medium resulted in a concentration-dependent increase in renin release from the slices. The stimulant effect of W-7 on renin release was abolished by the removal of calcium from the incubation medium. These results suggest that the inhibition of the calcium-calmodulin system leads to the stimulation of renin release from rat kidney cortical slices.
- 公益社団法人日本薬学会の論文
著者
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Ohno Yukihiro
Department Of Pharmacology Osaka College Of Pharmacy
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MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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MORIMOTO Shiro
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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MIYAWAKI NOBUAKI
Department of Pharmacology, Osaka College of Pharmacy
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Matsumura Yasuo
Department Of Pharmacology Osaka College Of Pharmacy
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Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
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Morimoto Shiro
Department Of Pharmacology Osaka College Of Pharmacy
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Miyawaki N
Department Of Pharmacology Osaka College Of Pharmacy
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Morimoto Shiro
Department of Chemical Engineering, Faculty of Engineering, Tokushima University
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