Inhibitory effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in the caudate nucleus.
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概要
- 論文の詳細を見る
Electrophysiological studies using reserpine-treated cats were carried out to elucidate the effects of L-threo-3, 4-dihydroxyphenylserine (L-threo-DOPS) on the noradrenergic pathway from the locus coeruleus (LC) to the caudate nucleus (CN) neurons, which were activated by iontophoretically applied bromocriptine, a dopamine D-2 receptor agonist. In the CN neurons, glutamate-induced firing was inhibited by iontophoretic application of noradrenaline, but not by repetitive stimulation of the LC or iontophoretically applied L-threo-DOPS. After intraventricular administration of L-threo-DOPS, however, LC stimulation inhibited the glutamate-induced firing. These results suggest that L-noradrenaline that was produced from the conversion of L-threo-DOPS inhibited the CN neurons which possess dopamine D-2 receptors.
- 公益社団法人 日本薬理学会の論文
著者
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Ohno Yukihiro
Department Of Pharmacology Osaka College Of Pharmacy
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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Hirose Akira
Department Of Electrical Engineering The University Of Tokyo
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OHNO Yukihiro
Department of Pharmacology, Faculty of Medicine, Kyoto University
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HIROSE Akira
Department of Pharmacology, Faculty of Medicine, Kyoto University
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