Cold Exposure Enhances Nitroxidergic Nerve-Mediated Vasodilatation in Canine Nasal Mucosa

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概要

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• We have previously reported that there is non-adrenergic, non-cholinergic (NANC) innervation in canine nasal mucosa and that the relaxation response to electrical stimulation of the NANC nerve is mainly mediated by nitric oxide (NO). In the present study, we examined the effect of cold exposure (24°C) on nitroxidergic nerve-mediated vasodilatation in isolated canine nasal mucosa. Nasal mucosa strips, prepared from canine nasal septum and moderately precontracted with methoxamine in the presence of atropine and guanethidine, relaxed in response to transmural electrical stimulation (square pulses of 0.5-msec duration, at 5 Hz and 25 V). The degree of relaxation at 24°C (55.4±13.2% of methoxamine-induced contraction, mean±S.D., n=6) was significantly greater than that at 34°C (33.8±8.6%, n=6). This phenomenon was reversible. In contrast, the magnitude of relaxation responses to an NO donor (sodium nitroprusside of 0.1 and 1 μM) remained unchanged by cold exposure. These results suggest that the release of NO from the nitroxidergic nerve endings is augmented by cold exposure and, thus, vasodilatation of the nasal blood vessel is enhanced, thereby contributing to the swelling of the nasal mucosa in cold conditions.

• 社団法人 日本薬理学会の論文
• 1998-08-01

著者

• Watanabe Hiroshi

  Department of Cardiology, Niigata City General Hospital

• SASA Masashi

  Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi

• Sasa Masashi

  広島大学 耳鼻咽喉科

• TSURU Hiromichi

  Department of Pharmacology, Toho University School of Medicine

• Tsuru Hiromichi

  Department Of Pharmacology Faculty Of Medicine Toho University

• YAJIN Koji

  Department of Otorhinolaryngology, Hiroshima University School of Medicine

• KAWAMOTO Hiroko

  Department of Otorhinolaryngology, Hiroshima University School of Medicine

• Sasa M

  Hiroshima Univ. School Of Medicine Hiroshima Jpn

• Yajin Koji

  Department Of Otorhinolaryngology Hiroshima University School Of Medicine

• Yajin Koji

  Department Of Otorhinolaryngology Hiroshima University Faculty Of Medicine

• Kawamoto Hiroko

  Department Of Otorhinolaryngology Hiroshima University School Of Medicine

• Kawamoto Hiroko

  Department Of Otolaryngology Head And Neck Surgery Hiroshima Prefecture Hospital

• Tsuru H

  Department Of Pharmacology Toho University School Of Medicine

• Watanabe H

  Department Of Otorhinolaryngology Hiroshima University School Of Medicine

• Watanabe Hiroshi

  Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers

• YAJIN Koji

  Department of Otolaryngology, Head and Neck Surgery, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University

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