GTS-21, a Nicotinic Agonist, Attenuates Multiple Infarctions and Cognitive Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
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概要
- 論文の詳細を見る
We examined the effects of GTS-21 [3-(2, 4-dimethoxybenzylidene)-anabaseine dihydrochloride], a nicotinic agonist, on histopathological changes of the brain and radial maze learning performance in rats with permanent occlusion of the bilateral common carotid arteries (2VO) and elucidated whether this compound has a protective effect against the neuronal degeneration and spatial cognitive deficit caused by chronic ischemia. Rats were administered GTS-21 (1 and 10 mg/kg, p.o.) or vehicle 24 hr and 30 min before the 2VO operation and then once daily for 2 months after the operation. The 2VO rats given vehicle had multiple infarctions in the cerebral cortex, hippocampus and striatum and rarefaction in the white matter at 2 months after the operation, although the number and distribution of infarctions varied among individual animals. In addition, the 2VO rats given vehicle showed a higher rate of errors in the acquisition trials of the 8-arm radial maze task than sham-operated controls. However, 2VO rats treated with GTS-21 (1 and 10 mg/kg, p.o.) showed significantly decreased neuropathological changes and less errors in the acquisition trials compared to the vehicle-treated 2VO rats. These results indicate that GTS-21 attenuates impairment of spatial cognitive deficit and progressive neuronal degeneration induced by 2VO and suggest that this compound is beneficial for the treatment of neurodegenerative diseases following chronic cerebral hypoperfusion.
- 社団法人 日本薬理学会の論文
- 1998-12-01
著者
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南里 真人
大鵬薬品工業株式会社 薬理研究所
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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MURAKAMI Yukihisa
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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Murakami Yukihisa
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Murakami Yuko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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南里 真人
Department Of Pharmacology Taiho Pharmaceutical Co. Ltd.
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NANRI Masato
Section of Pharmacology Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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MIYAKE Hidekazu
Section of Pharmacology Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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Miyake Hidekazu
Department Of Pharmacology Taiho Pharmaceutical Co. Ltd.
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Miyake Hidekazu
Cardiovascular Science Research Laboratory Hanno Research Center Taiho Pharmaceutical Co. Ltd.
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Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Murakami Y
Toho Univ. Chiba Jpn
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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