Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on Acute Inflammation in Experimental Animals
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概要
- 論文の詳細を見る
The effects of crude alkaloids extracted from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on acute inflammatory responses such as carrageenin-induced paw edema in rats and croton oil- and arachidonic acid-induced ear edema in mice were investigated. Oral administration of H. zeylanica alkaloid extract (200-400 mg/kg) significantly suppressed the paw swelling induced by carrageenin. In the croton oil-induced ear edema, topically applied H. zeylanica alkaloid extract, at doses of 200 and 400 mg/ml, also significantly reduced ear edema. Moreover, the extract (50-200 mg/kg, p. o.) reduced in a dose-dependent manner the ear swelling induced by topically applied arachidonic acid (2 mg/ear). These results suggest that the inhibitory effects of H. zeylanica alkaloid extract on acute edema formation are partly due to inhibition of 5-lipoxygenase and cyclooxygenase activity.
- 社団法人日本薬学会の論文
- 1995-01-15
著者
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坂井 進一郎
千葉大院薬
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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松本 欣三
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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渡辺 裕司
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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松本 欣三
富山大学和漢医薬学総合研究所複合薬物薬理学
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SUBHADHIRASAKUL Sanan
Department of Pharmaceutical Botany and Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince of
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REANMONGKOL Wantana
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and
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高山 広光
Thailand and Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Unive
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坂井 進一郎
Thailand and Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Unive
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Matsumoto Kinzo
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
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佐々木 茂貴
Faculty Of Pharmaceutical Sciences Kyushu University
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Reanmongkol Wantana
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And P
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坂井 進一郎
Thailand And Department Of Pharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Chiba Univers
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Subhadhirasakul Sanan
Department Of Pharmaceutical Botany And Pharmacognosy Faculty Of Pharmaceutical Sciences Prince Of S
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/ 松本
Division of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Subhadhirasakul Sanan
Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University
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渡辺 裕司
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
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