霊仙山(滋賀県)産イブキトリカブト(Aconitum ibukiense NAKAI)の塩基成分について

概要

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We have investigated the alkaloidal constituents of the roots of Aconitum ibukiense NAKAI cellected at Mt. Ryosen (Shiga Pref.). In addition to the known twelve compounds i.e. mesaconitine, hypaconitine, aconitine, deoxyaconitine, 14-dehydrobrowniine, 14-dehydrodelcosine, delcosine, takaonine, neoline, 15-α-hydroxyneoline, senbusine A, and ignavine, four new bases, i.e. ibukinamine, ryosenamine, ryosenaminol, and 9-hydroxynominine, were isolated. The structures of ibukinamine, ryosenamine, and ryosenaminol were established to be 2,3-dehydro-6-O-demethyldelcosine, 1-deoxyhypognavine, and 1-deoxyhypognavinol, respectively, by the spectroscopic evidence and by the X-ray crystallographic analyses. The structure of 9-hydroxynominine was deduced by the spectroscopic evidence.
社団法人日本薬学会の論文
1984-03-25