A New Indole Alkaloid, 14α-Hydroxyrauniticine : Structure Revision and Partial Synthesis
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概要
- 論文の詳細を見る
Oxidation of the enamine (6) with dibenzoyl peroxide followed by reduction with NaBH_4 gave the benzoate (8), which was converted to the cis-hydroxyl compound (9), while hydroboration-oxidation of 6 gave the trans-isomer (11). Treatment of a mixture of the enamines (13 and 14) with dibenzoyl peroxide/NaBH_4 gave the benzoates (15 and 16), which were converted to 14α-hydroxy-3-isorauniticine (17) and the acetal (18), respectively. Hydroboration-oxidation of 13 gave 14α-hydroxyrauniticine (2), which was found to be identical with the natural alkaloid whose structure had erroneously been proposed as 14β-hydroxy-3-isorauniticine (4).
- 公益社団法人日本薬学会の論文
- 1986-09-25
著者
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Ponglux Dhavadee
チュラロンコン大学薬学部
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相見 則郎
千葉大院葉
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相見 則郎
Faculty Of Pharmaceutical Sciences University Of Tokyo
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坂井 進一郎
千葉大院薬
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PONGLUX Dhavadee
Faculty of Pharmaceutical Sciences, Chulalongkorn University
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坂井 進一郎
Faculty of Pharmaceutical Sciences, Chiba University
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WONGSERIPIPATANA Sumphan
Faculty of Phamraceutical Sciences, Chulalongkorn University
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山中 悦二
Department Of Medicinal Materials:faculty Of Pharmaceutical Sciences Chiba University
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山中 悦二
Faculty of Pharmaceutical Sciences, Chiba University
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笠松 里江
Faculty of Pharmaceutical Sciences, Chiba University
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丸田 悦子
Faculty of Pharmaceutical Sciences, Chiba University
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SUPAVITA TANOMJIT
Faculty of Pharmaceutical Sciences, Chulalongkorn University
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PHILLIPSON J.
Thailand, and Department of Pharmacognosy, The School of Pharmacy
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Ponglux Dhavadee
Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Wongseripipatana Sumphan
Faculty Of Phamraceutical Sciences Chulalongkorn University
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坂井 進一郎
Faculty Of Pharmaceutical Sciences Chiba University
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Phillipson J.
Thailand And Department Of Pharmacognosy The School Of Pharmacy
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Ponglux Dhavadee
Faculty Of Phamraceutical Sciences Chulalongkorn University
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Supavita Tanomjit
Faculty Of Pharmaceutical Sciences Chulalongkorn University
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丸田 悦子
Faculty Of Pharmaceutical Sciences Chiba University
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笠松 里江
Faculty Of Pharmaceutical Sciences Chiba University
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