Organic Phosphates. XIX. A Novel Phosphorylation of Nucleosides and Related Compounds with Hydrobenzoin Cyclic Phosphate activated by Diphenyl Phosphorochloridate.

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概要

• 論文の詳細を見る

• Hydrobenzoin cyclic phosphate, diphenyl phosphorochloridate, and tributylamine were reacted with several hydroxylic compounds (ROH) at 37° for 24〜50 hours and the resulting phosphotriesters of type [chemical formula] were hydrolyzed to phosphodiesters (esters of 1,2-diphenyl-2-hydroxyethyl phosphate) which were catalytically hydrogenated to liberate hydrobenzoin moiety and gave the phosphoryl esters of the hydroxylic compounds used. The reaction was applied to butanol, methyl ribofuranoside to detect the corresponding phosphates. And the method was used for the preparative phosphorylation of methyl 2,3-O-isopropylideneribofuranoside, 2', 3'-O-isopropylideneuridine and 5'-O-trityluridine.

• 社団法人日本薬学会の論文
• 1962-11-25

著者

• 相見 則郎

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 長沢 金蔵

  School Of Pharmaceutical Sciences Kitasato University

• 浮田 忠之進

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 井村 伸正

  東京大学薬学部

• 井村 伸正

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 長沢 金蔵

  Seikagaku Kogyo Co. Ltd.

• 浮田 忠之進

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

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