Syntheses of 1-(5'-Amino-5'-deoxy-β-D-xylofuranosyl) uracil and Its N_3-Methyl Derivative
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概要
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1-(5'-Amino-5'-deoxy-β-D-xylofuranosyl) uracil (VIII) and N_3-methyl-1-(5'-amino-5'-deoxy-β-D-xylofuranosyl) uracil (IX) were synthesized by catalytic reduction of the respective 5'-azido nucleosides, which were obtained by nucleophilic attack of 1-(3,'5'-epoxy-β-D-xylofuranosyl) uracil (IV) or 1-(5'-halogeno-5'-deoxy-β-D-xylofuranosyl) uracils (II) and N_3-methyl-1-(3', 5'-epoxy-β-D-xylofuranosyl) uracil (V) or N_3-methyl-1-(5'-iodo-5'-deoxy-β-D-xylofuranosyl) uracil (III) by lithium azide in dimethylformamide. The structures of the products (VIII and XI) were firmly established.
- 社団法人日本薬学会の論文
- 1969-04-25
著者
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日馬 恒雄
Exploratory Research Laboratories I Daiichi Pharmaceutical Co. Ltd.
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菊川 清見
Tokyo College of Pharmacy
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浮田 忠之進
Faculty of Pharmaceutical Sciences, University of Tokyo
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市野 元信
Faculty of Pharmaceutical Sciences, University of Tokyo
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市野 元信
Research Laboratories Kohjin Company Ltd.:(present Address)kitasato Biochemical Laboratories Bristol
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市野 元信
Faculty Of Agriculture University Of Tokyo
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浮田 忠之進
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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