Cross-Linking Reaction of a valency Asymmetrical Hybrid Hemoglobin Formed in a Mixture of Hemoglobin A and Methemoglobin
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It is known that hemoglobin A [Hb A (α_2β_2)] is cross-linked by reaction with double-headed aspirin [bis (3,5-dibromosalicyl)fumarate], and the cross-linking site is the β-cleft of the tetramer, the binding site of 2,3-diphosphoglycerate. Reaction of methemoglobin [metHb (α_2^+β_2^+)] with the reagent resulted in the formation of MetHbFu, which was confirmed to be a MetHb tetramer intramolecularly cross-linked at the same site. Unstable valency asymmetrical hybrid hemoglobin [Hb AM (αα^+ββ^+)], which is assumed to be present in a mixture of Hb A and MetHb, could be fixed as a stable tetramer [HbAMFu] by the cross-linking reaction. The intramolecular cross-links in HbAMFu were at the same β-cleft. It is suggested that MetHb forms the valency asymmetrical hybrid in the presence of Hb A.
- 公益社団法人日本薬学会の論文
- 1986-01-25
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