Platelet Aggregation Inhibitors. X. S-Substituted 2-Thioadenosines and Their Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A series of S-substituted 2-thioadenosines (IV) were prepared by treatment of 2-thioadenosine (III) with a requisite halide in NaOH-H_2O, NaOH-H_2O-EtOH, Na/dimeth-ylformamide, NaOMe/dimethylformamide or NaH/dimethylformamide. N-Substituted 2-aminoadenosines (V) were obtained by treatment of 2-chloroadenosine (II) with a requisite amine. Compounds (IV and V) and N-oxide derivatives of them were tested as inhibitors of adenosine 5'-diphosphate- and collagen-induced rabbit platelet aggregation. 2-Cycloalkyl- or 2-polycycloalkylthioadenosines (IV_<7-9>), water-soluble 2-piperazino-ethylthioadenosines (IV_<16-19>) and 2-thioadenosine N-oxide (X_2) were found effective. Most of them showed long lasting activity during the incubation with rabbit plasma. Compounds (IV_<7-9>) were also inhibitory against human platelet aggregation.
- 公益社団法人日本薬学会の論文
- 1977-10-25
著者
-
菊川 清見
Tokyo College of Pharmacy
-
菊川 清見
Research Laboratory, Division of Fermentation and Chemical Products, Kohjin Co., Ltd.
-
末広 日出男
Research Laboratories, Kohjin Company, Ltd.
-
青木 旦治
Research Laboratories, Kohjin Company, Ltd.
-
末広 日出男
Research Laboratories Kohjin Company Ltd.
-
青木 旦治
Research Laboratories Kohjin Company Ltd.
関連論文
- Modification of Delipidated Apoprotein B of Low Density Lipoprotein by Lipid Oxidation Products in Relation to Macrophage Scavenger Receptor Binding
- Urinary Excretion of Thiobarbituric Acid Reactive Substances of Healthy Subjects Supplemented with a High Dose of d-α-Tocopherol
- Binding and Uptake of Oxidized Low Density Lipoprotein (LDL) by Macrophage Scavenger Receptors Are Enhanced by Substrate-Bound Fibronectin
- Evidence for Accumulation of Lipid Hydroperoxides during the Aging of Human Red Blood Cells in the Circulation
- A Simple Method for the Assessment of Macrophage Scavenger Receptor-Ligand Interaction : Adherence of Erythrocytes Coated with Oxidized Low Density Lipoprotein and Modified Albumin to Macrophages
- Intraction of Malondialdehyde-Modified Bovine Serum Albumin and Mouse Peritoneal Macrophages
- Formation of Cross-Links and Fluorescence in Polylysine : Soluble Proteins and Membrane Proteins by Reaction with 1-Butanal
- Fluorescent and Cross-Linked Proteins of Human Erythrocyte Ghosts Formed by Reaction with Hydroperoxylinoleic Acid, Malonaldehyde and Monofunctional Aldehydes
- Formation of Direct-Acting Mutagens in Coffee by Treatment with Nitrite
- Formation of a Direct Mutagen, Diazo-N-nitrosoetilefrin, by Interaction of Etilefrin with Nitrite
- Syntheses of 1-(5'-Amino-5'-deoxy-β-D-xylofuranosyl) uracil and Its N_3-Methyl Derivative
- Inactivation of Mutagenic Heterocyclic and Aryl Amines by Linoleic Acid 13-Monohydroperoxide and Methemoglobin
- Studies on the Vilsmeier-Haack Reaction. II. Characterization of Thionyl Chloride-Dimethylformamide Complexes
- Studies on the Vilsmeier-Haack Reaction. III. Synthesis of Cytidine Diphosphate Choline
- Influence of Frying and Baking on Chlorpropham Residue
- Fluorometric Determination of Malonaldehyde in Oxidized Lipids(Environmental,Chemical)
- Oxidation Products of Linoleate and Linolenate Exposed to Nitrogen Dioxide(Environmental)
- Synthesis of α-Substituted Alkanoic Acids and Inhibition of Platelet Aggregation
- Platelet Aggregation Inhibitors. X. S-Substituted 2-Thioadenosines and Their Derivatives
- Transformation of Adenosine into N_3,3'- and N_3,5'-Cycloadenosines via the Reactions with Sulfuryl Chloride and Thionyl Chloride
- Platelet Aggregation Inhibitors. IX. Chemical Transformation of Adenosine into 2-Thioadenosine Derivatives
- Platelet Aggregation Inhibitors. VIII. 2-Thioadenine Derivatives
- Studies on the Structure of a New Type of Cyclonucleoside, 6,2'-Triazacyclocytidine
- Reaction of Pyrimidine Nucleosides with Sulfuryl Chloride
- Alteration of 5-Chloropyrimidine Nucleosides in Alkaline Media
- Platelet Aggregation Inhibitors. V. Pyrimidine Derivatives, Indole Derivatives, Benzothiophenes, and Benzoquinolizine Derivative
- Effect of Plasma pH on Stability and Capacity of Aggregation of Platelets
- Platelet Aggregation Inhibitors. I. Hydroxylamine : A Potent Inhibitor of Platelet Aggregation
- Synthesis of a Nucleotide Coenzyme, CDP-Choline
- Reactions of Methyl Iodide on 2,2'-Anhydro-1-(β-D-arabinofuranosyl)-uracil and 2,3'-Anhydro-1-(β-D-xylofuranosyl) uracil
- Reaction of Hydrogen Halides on 2,3'-Anhydro-1-(β-D-xylofuranosyl) uracil
- Contribution of Alkadienals and/or Alkenals in the Ferric and Ferrous Ion-Enhanced TBA-Reactivity of Oxidized Oils
- Is the Thiobarbituric Acid-Reactivity of Blood Plasma Specific to Lipid Peroxidation?
- Polysines Modified with Malonaldehyde, Hydroperoxylinoleic Acid and Monofunctional Aldehydes
- Studies on Peroxidized Lipids : Fluorescent Products Derived from the Reaction of Unsaturated Fatty Acids and Methylamine
- Effect of tert-Butylhydroquinone (TBHQ) on the Formation of Nitrosamines in the Reaction of Secondary Amines with Nitrite
- Thiamine Is a Precursor of DNA Strand Breakage and Mutagenic Substance (s) When Mixed with Nitrite
- Generation of a Carbon-Centered Radical with DNA-Breaking Activity from Mutagenic Fluorene-2-Diazonium Salt
- Examination of the Extraction Methods and Re-evaluation of Blue Fluorescence Generated in Rat Tissues in Situ
- Characteristics of Fluorescence Formed by the Reaction of Proteins with Unsaturated Aldehydes, Possible Degradation Products of Lipid Radicals
- Formation of Fluorescent Products in the Reaction of Butyraldehyde and Methylamine as a Model of the Reaction of Oxidized Lipids and Proteins
- Studies on Peroxidized Lipids. II. Fluorescent Products Relevant to Aging Pigments derived from Malondialdehyde and Methylamine
- Variations in the Level of Urinary Thiobarbituric Acid Reactant in Healthy Humans under Different Physiological Conditions
- Studies on the Antioxidants. XIV. : Reaction of Sesamol with Hydrogen Peroxide-Peroxidase
- Interaction of Hemoglobin A with Sesamol and Polyphenolics
- Studies on the Antioxidants. XII. Combination Effects of Antioxidants on the Reduction of Ferric Ions
- Studies on the Antioxidants. XIII. Hydrogen Donating Capability of Antioxidants to 2,2-Diphenyl-1-picrylhydrazyl
- The Butylated Hydroxyanisole-Nitrite Reaction : Effects on N-Nitrosodimethylamine Formation in Model Systems
- C-Nitrosation of Sesamol and Its Effects on N-Nitrosamine Formation in Vitro
- Oxidation of Sesamol Dimer by Active Species produced in the Interaction of Peroxide and Hemoglobin
- Transformation of Hemoglobin by Various Peroxides in Vitro
- Studies on Peroxidized Lipids. III. Fluorescent Pigments derived from the Reaction of Malonaldehyde and Amino Acids
- Factors Influencing the Autoxidation of Hemoglobin A
- Properties of Conjugated Schiff Bases of Malonaldehyde
- Role of Heme Compounds in the Erythrocyte Membrane Damage Induced by Lipid Hydroperoxide(Biological)
- Inhibition of Nitrosamine Formation by Inorganic and Organic Salts
- Formation of Nitrosamines in Organic Solvents and Aqueous Systems Containing Organic Solvents
- Fluorescence of 1,4-Dihydropyridine Derivatives Relevant to Age Pigments(Environmental,Chemical)
- Studies on the Intermediates of Methemoglobin by the Use of a Cross-Linking Agent
- Studies on Peroxidized Lipids. I. Interaction of Malondialdehyde with Secondary Amines and Its Relevance to Nitrosamine Formation
- Cross-Linking Reaction of a valency Asymmetrical Hybrid Hemoglobin Formed in a Mixture of Hemoglobin A and Methemoglobin