Oxidation of Sesamol Dimer by Active Species produced in the Interaction of Peroxide and Hemoglobin
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概要
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Sesamol dimer (I) was converted into the quinone (II) having an absorption maximum at 550 nm by treatment with hydrogen peroxide, linoleic acid hydroperoxide or tert-butyl hydroperoxide in the presence of hemoglobin. The order of the color-forming activity was linoleic acid hydroperoxide≫hydrogen peroxide>tert-butyl hydroperoxide. Methemoglobin was much more effecive than oxyhemoglobin for coloration. Hydrogen peroxide and methemoglobin produced a complex which generated singlet oxygen and hydroxyl radical, the latter being effective for coloration of I. The reaction of linoleic acid hydroperoxide with methemoglobin produced a complex which generated peroxy free radical and then the keto acid and singlet oxygen ; the peroxy free radical was found to be the active species for oxidation of I. Sesamol dimer (I) may be useful for chromogenic assay of hydroxyl and peroxy free radicals.
- 公益社団法人日本薬学会の論文
- 1983-02-25
著者
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菊川 清見
Tokyo College of Pharmacy
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呉地 伝夫
Tokyo College of Pharmacy
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呉地 伝夫
東京薬科大学
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笹原 富弥
Tokyo College of Pharmacy
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