Studies on Peroxidized Lipids. I. Interaction of Malondialdehyde with Secondary Amines and Its Relevance to Nitrosamine Formation
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概要
- 論文の詳細を見る
Malondialdehyde (MDA) reacted with secondary amines (dimethylamine, diethylamine, piperidine, pyrrolidine and morpholine) at 37° under mild acidic or neutral conditions to yield β-dialkylaminoacroleins (1-5) of trans, s-trans conformation. The optimal pH of the reaction was 3-5,and the yields were 15-55% in a 6 hr incubation. The acroleins (1-5) were unstable under acidic and alkaline conditions, and produced a pink color on reaction with 2-thiobarbituric acid. β-Dimethylaminoacrolein (1) could be readily nitrosated in the acidic pH range to produce N-nitrosodimethylamine, and the rate of nitrosamine formation from 1 at pH 5.0 was much higher than that from dimethylamine ; this is consistent with earlier observations of the stimulating effect of MDA on nitrosamine formation.
- 公益社団法人日本薬学会の論文
- 1980-11-25
著者
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菊川 清見
Tokyo College of Pharmacy
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呉地 伝夫
Tokyo College of Pharmacy
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呉地 伝夫
東京薬科大学
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呉地 傅夫
Tokyo College of Pharmacy
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築田 浩一
Tokyo College of Pharmacy
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