Formation of Direct-Acting Mutagens in Coffee by Treatment with Nitrite
スポンサーリンク
概要
- 論文の詳細を見る
Coffee produced mutagenicity on Salmonella typhimurium TA98 and TA100 without metabolic activation on treatment with nitrite under mildly acidic conditions. The mutagenicity of one cup of instant coffee (1 g of coffee powder in 100 ml of water) treated with 10 mmol nitrite at pH 3 and 37℃ for 1 h was estimated to be 3.2 and 8.8×10^4 His^+ revertant colonies/plate for TA98 and TA100,respectively. The major mutagen (s) were partially purified by extraction with chloroform and adsorption to blue cotton. The mutagen (s) were separated by high performance liquid chromatography using reverse phase columns, and a mutagenic fraction with a single sharp ultraviolet-absorbing peak was obtained. His^+ revertant colonies of this fraction per cup of instant coffee equivalent was 488 on TA98 and 300 on TA100 without metabolic activation.
- 社団法人日本薬学会の論文
- 1993-06-30
著者
関連論文
- Modification of Delipidated Apoprotein B of Low Density Lipoprotein by Lipid Oxidation Products in Relation to Macrophage Scavenger Receptor Binding
- Urinary Excretion of Thiobarbituric Acid Reactive Substances of Healthy Subjects Supplemented with a High Dose of d-α-Tocopherol
- Binding and Uptake of Oxidized Low Density Lipoprotein (LDL) by Macrophage Scavenger Receptors Are Enhanced by Substrate-Bound Fibronectin
- Evidence for Accumulation of Lipid Hydroperoxides during the Aging of Human Red Blood Cells in the Circulation
- A Simple Method for the Assessment of Macrophage Scavenger Receptor-Ligand Interaction : Adherence of Erythrocytes Coated with Oxidized Low Density Lipoprotein and Modified Albumin to Macrophages
- Intraction of Malondialdehyde-Modified Bovine Serum Albumin and Mouse Peritoneal Macrophages
- Formation of Cross-Links and Fluorescence in Polylysine : Soluble Proteins and Membrane Proteins by Reaction with 1-Butanal
- Fluorescent and Cross-Linked Proteins of Human Erythrocyte Ghosts Formed by Reaction with Hydroperoxylinoleic Acid, Malonaldehyde and Monofunctional Aldehydes
- Formation of Direct-Acting Mutagens in Coffee by Treatment with Nitrite
- Formation of a Direct Mutagen, Diazo-N-nitrosoetilefrin, by Interaction of Etilefrin with Nitrite
- Syntheses of 1-(5'-Amino-5'-deoxy-β-D-xylofuranosyl) uracil and Its N_3-Methyl Derivative
- Inactivation of Mutagenic Heterocyclic and Aryl Amines by Linoleic Acid 13-Monohydroperoxide and Methemoglobin
- Studies on the Vilsmeier-Haack Reaction. II. Characterization of Thionyl Chloride-Dimethylformamide Complexes
- Studies on the Vilsmeier-Haack Reaction. III. Synthesis of Cytidine Diphosphate Choline
- Influence of Frying and Baking on Chlorpropham Residue
- Fluorometric Determination of Malonaldehyde in Oxidized Lipids(Environmental,Chemical)
- Oxidation Products of Linoleate and Linolenate Exposed to Nitrogen Dioxide(Environmental)
- Synthesis of α-Substituted Alkanoic Acids and Inhibition of Platelet Aggregation
- Platelet Aggregation Inhibitors. X. S-Substituted 2-Thioadenosines and Their Derivatives
- Transformation of Adenosine into N_3,3'- and N_3,5'-Cycloadenosines via the Reactions with Sulfuryl Chloride and Thionyl Chloride
- Platelet Aggregation Inhibitors. IX. Chemical Transformation of Adenosine into 2-Thioadenosine Derivatives
- Platelet Aggregation Inhibitors. VIII. 2-Thioadenine Derivatives
- Studies on the Structure of a New Type of Cyclonucleoside, 6,2'-Triazacyclocytidine
- Reaction of Pyrimidine Nucleosides with Sulfuryl Chloride
- Alteration of 5-Chloropyrimidine Nucleosides in Alkaline Media
- Platelet Aggregation Inhibitors. V. Pyrimidine Derivatives, Indole Derivatives, Benzothiophenes, and Benzoquinolizine Derivative
- Effect of Plasma pH on Stability and Capacity of Aggregation of Platelets
- Platelet Aggregation Inhibitors. I. Hydroxylamine : A Potent Inhibitor of Platelet Aggregation
- Synthesis of a Nucleotide Coenzyme, CDP-Choline
- Reactions of Methyl Iodide on 2,2'-Anhydro-1-(β-D-arabinofuranosyl)-uracil and 2,3'-Anhydro-1-(β-D-xylofuranosyl) uracil
- Reaction of Hydrogen Halides on 2,3'-Anhydro-1-(β-D-xylofuranosyl) uracil
- Contribution of Alkadienals and/or Alkenals in the Ferric and Ferrous Ion-Enhanced TBA-Reactivity of Oxidized Oils
- Is the Thiobarbituric Acid-Reactivity of Blood Plasma Specific to Lipid Peroxidation?
- Polysines Modified with Malonaldehyde, Hydroperoxylinoleic Acid and Monofunctional Aldehydes
- Studies on Peroxidized Lipids : Fluorescent Products Derived from the Reaction of Unsaturated Fatty Acids and Methylamine
- Effect of tert-Butylhydroquinone (TBHQ) on the Formation of Nitrosamines in the Reaction of Secondary Amines with Nitrite
- Thiamine Is a Precursor of DNA Strand Breakage and Mutagenic Substance (s) When Mixed with Nitrite
- Generation of a Carbon-Centered Radical with DNA-Breaking Activity from Mutagenic Fluorene-2-Diazonium Salt
- Examination of the Extraction Methods and Re-evaluation of Blue Fluorescence Generated in Rat Tissues in Situ
- Characteristics of Fluorescence Formed by the Reaction of Proteins with Unsaturated Aldehydes, Possible Degradation Products of Lipid Radicals
- Formation of Fluorescent Products in the Reaction of Butyraldehyde and Methylamine as a Model of the Reaction of Oxidized Lipids and Proteins
- Studies on Peroxidized Lipids. II. Fluorescent Products Relevant to Aging Pigments derived from Malondialdehyde and Methylamine
- Variations in the Level of Urinary Thiobarbituric Acid Reactant in Healthy Humans under Different Physiological Conditions
- Studies on the Antioxidants. XIV. : Reaction of Sesamol with Hydrogen Peroxide-Peroxidase
- Interaction of Hemoglobin A with Sesamol and Polyphenolics
- Studies on the Antioxidants. XII. Combination Effects of Antioxidants on the Reduction of Ferric Ions
- Studies on the Antioxidants. XIII. Hydrogen Donating Capability of Antioxidants to 2,2-Diphenyl-1-picrylhydrazyl
- The Butylated Hydroxyanisole-Nitrite Reaction : Effects on N-Nitrosodimethylamine Formation in Model Systems
- C-Nitrosation of Sesamol and Its Effects on N-Nitrosamine Formation in Vitro
- Oxidation of Sesamol Dimer by Active Species produced in the Interaction of Peroxide and Hemoglobin
- Transformation of Hemoglobin by Various Peroxides in Vitro
- Studies on Peroxidized Lipids. III. Fluorescent Pigments derived from the Reaction of Malonaldehyde and Amino Acids
- Factors Influencing the Autoxidation of Hemoglobin A
- Properties of Conjugated Schiff Bases of Malonaldehyde
- Role of Heme Compounds in the Erythrocyte Membrane Damage Induced by Lipid Hydroperoxide(Biological)
- Inhibition of Nitrosamine Formation by Inorganic and Organic Salts
- Formation of Nitrosamines in Organic Solvents and Aqueous Systems Containing Organic Solvents
- Fluorescence of 1,4-Dihydropyridine Derivatives Relevant to Age Pigments(Environmental,Chemical)
- Studies on the Intermediates of Methemoglobin by the Use of a Cross-Linking Agent
- Studies on Peroxidized Lipids. I. Interaction of Malondialdehyde with Secondary Amines and Its Relevance to Nitrosamine Formation
- Cross-Linking Reaction of a valency Asymmetrical Hybrid Hemoglobin Formed in a Mixture of Hemoglobin A and Methemoglobin