Thiamine Is a Precursor of DNA Strand Breakage and Mutagenic Substance (s) When Mixed with Nitrite
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概要
- 論文の詳細を見る
DNA strand breakage activity and mutagenicity of the product (s) formed by a reaction of thiamine and nitrite under simulated gastric conditions were examined. A reaction mixture of thiamine and nitrite at pH 3 induced DNA single-strand breaks when incubated with a supercoiled plasmid DNA at pH 7.4 and 37℃. Product (s) from thiamine and nitrite were found mutagenic to Salmonella typhimurium TA100 strain without metabolic activation. The number of His^+ revertant colonies was 1200/10-μmol eq of thiamine. Hence, thiamine is an undesirable precursor of DNA strand breakage and mutagenic substance (s) when mixed with nitrite.
- 公益社団法人日本薬学会の論文
- 1995-12-31
著者
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菊川 清見
Tokyo College of Pharmacy
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加藤 哲太
Tokyo College of Pharmacy
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菊川 清見
東薬大・薬・衛生化学
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平本 一幸
東京薬大・薬
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加藤 哲太
東京薬科大学薬学部
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加藤 哲太
東京薬科大学薬学部薬学科
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新山 弘美
東京薬科大学
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平本 一幸
東京薬科大学薬学部
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平本 一幸
Tokyo College of Pharmacy
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新山 弘美
Tokyo College of Pharmacy
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