Recognition of Poly-N-acetyllactosaminyl Saccharide Chains on Iron-Oxidized Erythrocytes by Human Monocytic Leukemia Cell Line THP-1 Differentiated into Macrophages
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概要
- 論文の詳細を見る
The cells of the human monocytic leukemia cell line THP-1 differentiated into macrophages bound to human erythrocytes oxidized with adenosine 5'-diphosphate (ADP)-Fe^<3+> chelate (ADP/Fe^<3+>) in the absence of serum. The binding was prevented when the cells were treated with ADP/Fe^<3+> in the presence of antioxidants, indicating that oxidation of the cells is responsible for the increased susceptibility to the THP-1 cell binding. Galactose, fucose, mannose and mannan partially inhibited the binding. Glycoproteins containing poly-N-acetyllactosaminyl saccharide chains such as band 3 glycoprotein isolated from human erythrocyte membrane and lactoferrin, and their oligosaccharides, strongly inhibited the binding. On the other hand, glycoproteins with non-poly-N-acetyl-lactosaminyl saccharide chains such as glycophorin A isolated from the erythrocyte membrane, fetuin and α_1-acid glycoprotein, little or partially inhibited the binding. The inhibitory activity of band 3 oligosaccharides and lactoferrin oligosaccharides was little affected by treatment with endo-β-galactosidase, which specifically cleaves poly-N-acetyllactosamine to shorter oligosaccharides. Removal of the nonreducing terminal region of the saccharide chains of band 3 on the eythrocyte surface by treatment of the cells with endo-β-galactosidase resulted in a decrease in the susceptibility of the cells to the THP-1 cell binding. These results suggest that THP-1 cells which have been differentiated into macrophages bind the oxidized erythrocytes primarily through the recognition of poly-N-acetyllactosaminyl saccharide chains of band 3,and the site of the recognition exists in the nonreducing terminal region of the saccharide chains. Clustering of band 3 molecules is proposed as a possible alteration of oxidized erythrocyte membrane which promotes the interaction of the saccharide receptor on THP-1 cells with the saccharide chains of band 3 on erythrocytes.
- 社団法人日本薬学会の論文
- 1996-02-15
著者
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別府 正敏
東京薬大 公衆衛生学
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別府 正敏
東京薬科大学
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別府 正敏
東京医科大学 小児科学
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EDA Shigetoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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KIKUGAWA Kiyomi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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BEPPU Masatoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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FUJIMAKI Mayumi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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HISHIYAMA Eisuke
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Eda Shigetoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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菊川 清見
東薬大・薬・衛生化学
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Beppu M
Tokyo College Of Pharmacy
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Beppu Masatoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Fujimaki Mayumi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Hishiyama Eisuke
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Beppu Masatoshi
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Kikugawa Kiyomi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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