Enhanced Adhesion of Oxidized Mouse Polymorphonuclear Leukocytes to Macrophages by a Cell-Surface Sugar-Dependent Mechanism
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概要
- 論文の詳細を見る
Mouse thioglycollate-induced peritoneal macrophages effectively, in the absence of serum, recognized mouse polymorphonuclear leukocytes (PMNs) mildly oxidized with diamide, superoxide (hypoxanthine/xanthine oxidase) or t-butylhydroperoxide, or modified with N-ethylmaleimide (NEM). The recognition reached a maximum when PMNs were treated wtih each of the reagents at relatively low concentrations, and the recognition was decreased on treatment with reagents at higher concentrations. Glutathione depletion in the diamide-oxidized PMNs may cause enhanced adhesion to macrophages. Sialylated sugar chains attached to a peptide chain in glycophorin A and sialylated poly-N-acetyllactosaminyl sugar chains in lactoferrin and band 3 glycoprotein effectively inhibited the increased adhesion of the diamide-oxidized PMNs. Enzymatic removal of sialyl residues and the degradation of poly-N-acetyllactosaininyl sugar chains by pretreatment of PMNs with neuraminidase or endo-β-galactosidase, respectively, lost their increasing ability for macrophage adhesion after oxidation with diamide, superoxide or t-butylhydroperoxide. Clustered sialylated poly-N-acetyllactosaminyl sugar chains on the cell surface may be involved in the increased adhesion of the oxidized PMNs to macrophages.
- 公益社団法人日本薬学会の論文
- 2001-01-01
著者
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KIKUGAWA Kiyomi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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BEPPU Masatoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Beppu Masatoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Beppu Masatoshi
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Kikugawa Kiyomi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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YOKOYAMA Noriaki
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MOTOHASHI Masatoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Yokoyama N
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Motohashi Masatoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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