Inhibition of the Activity of Mouse Macrophage Scavenger Receptors by Antioxidants
スポンサーリンク
概要
- 論文の詳細を見る
Effect of exogenously added antioxidants on the activity of the mouse macrophage scavenger receptors for oxidized low density lipoprotein (oxLDL) was investigated. Binding of oxLDL-coated erythrocytes and/or 125I-oxLDL to a monolayer of thioglycollate-induced peritoneal macrophages preincubated with antioxidants at 37°C for 2 h was examined. The binding was effectively or slightly decreased by preincubation of macrophages with probucol, butylated hydroxytoluene, α-tocopherol, sesamol, propyl gallate, quercetin, nordihydroguaiaretic acid, epicatechin gallate, epigallocatechin gallate (EGCg), glutathione isopropyl ester (GSH-Pr), N-acetylcysteine, ascorbic acid, erythorbic acid, and Desferal at concentrations lower than 100 μM. The binding was slightly enhanced by preincubation of macrophages with buthionine sulfoximine. The antioxidants and related compounds inhibited the formation of foam cells induced by oxLDL in the prolonged incubation for 24 h. Glutathione, oxidized glutathione and dehydroascorbic acid inhibited the foam cell formation, Total cholesterol accumulation induced by oxLDL in the prolonged incubation was reduced by the phenolic antioxidants. The number of scavenger receptors of macrophages was unchanged upon treatment with EGCg and GSH-Pr. The results indicate that the antioxidants at relatively high concentrations inhibited macrophage functions, binding of oxLDL, foam cell formation, and accumulation of cholesterol, and suggest that the scavenger receptor activity of macrophages was exerted by certain oxidative mechanisms.
- 日本油化学会の論文
- 2001-04-01
著者
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渡辺 光男
Hamamatsu Photonics K. K.
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渡部 俊彦
東北薬大
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別府 正敏
東京薬大 公衆衛生学
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別府 正敏
東京薬科大学
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別府 正敏
東京医科大学 小児科学
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KIKUGAWA Kiyomi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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BEPPU Masatoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Watanabe M
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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菊川 清見
東薬大・薬・衛生化学
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Beppu M
Tokyo College Of Pharmacy
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Beppu Masatoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Watanabe M
Department Of Public Health Niigata College Of Medical Technology
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WATANABE Mitsuhiro
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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WATANABE Takuji
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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KASAHARA Masaaki
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Beppu Masatoshi
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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菊川 清見
東京薬科大学薬学部
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Kikugawa Kiyomi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Kasahara Masaaki
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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