Increased Urinary Hydrogen Peroxide Levels Caused by Coffee Drinking

スポンサーリンク

概要

• 論文の詳細を見る

• Experiments with volunteers in Singapore have demonstrated that coffee drinking increases urinary hydrogen peroxide levels (Long, Halliwell, Free Rad. Res., 32, 463-467 (2000)). We re-examined the effect of coffee drinking of healthy Japanese subjects on urinary hydrogen peroxide levels. A cup of brewed or canned coffee commercially available in Japan generated 120-420 μmol hydrogen peroxide in incubation in a neutral medium at 37℃ for 6 h. The increased levels were higher than those obtained from a cup of green tea extract or a glass of red wine. After the subject drank a cup of coffee, apparent hydrogen peroxide levels (μmol/g creatinine) in urine collected 1-2 h after coffee drinking increased 3-10-fold compared to the levels before coffee drinking. The increased urinary hydrogen peroxide levels are likely derived mainly from 1,2,4-beazenetriol excreted in urine, because the major component that generates hydrogen peroxide is found to be 1,2,4-benzenetriol, and storing urine collected after coffee drinking increased hydrogen peroxide levels in a time-dependent fashion. Total hydrogen peroxide equivalent levels excreted in 3 h-urine after coffee drinking were estimated to be 0.5-10% that of coffee consumed. A residual amount of hydrogen peroxide may be retained or consumed in human bodies.

• 公益社団法人日本薬学会の論文
• 2002-11-01

著者

• Hiramoto K

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

• Hiramoto Kazuyuki

  School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• Kikugawa Kiyomi

  School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• KIDA Tomoko

  School of Pharmacy Tokyo University of Pharmacy and Life Science

• Kida T

  School Of Pharmacy Tokyo University Of Pharmacy And Life Science

関連論文

• Characterization of Lactoferrin-Binding Proteins of Human Macrophage Membrane : Multiple Species of Lactoferrin-Binding Proteins with Polylactosamine-Binding Ability
• Recognition of Poly-N-acetyllactosaminyl Saccharide Chains on Iron-Oxidized Erythrocytes by Human Monocytic Leukemia Cell Line THP-1 Differentiated into Macrophages
• Binding Characteristics of Human Lactoferrin to the Human Monocytic Leukemia Cell Line THP-1 Differentiated into macrophages
• Effect of Supplementation of n-3 Polyunsaturated Fatty Acids on Oxidative Stress-Induced DNA Damage of Rat Hepatocytes(Biochemistry/Molecular Biology)
• Effect of Supplementation of a Reductone in Coffee, Hydroxyhydroquinone, on Lipid Peroxidation and DNA Damage of Rat Organs
• Inhibition of Iron-Induced Oxidative Damage of Erythrocyte Membranes and Low Density Lipoprotein by a Mailard Product, 4-Hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H-furanone (HEMF)
• Effect of Feeding Plant Polyphenolics on Fatty Acid Composition, Vitamin E Level and Degree of Lipid Peroxidation in Rat Organs
• Participation of the Arachidonic Acid Cascade Pathway in Macrophage Binding / Uptake of Oxidized Low Density Lipoprotein
• Inhibition of the Activity of Mouse Macrophage Scavenger Receptors by Antioxidants
• Cholesterol Synthesis in Mice Is Suppressed but Lipofuscin Formation Is Not Affected by Long-Term Feeding of n-3 Fatty Acid-Enriched Oils Compared with Lard and n-6 Fatty Acid-Enriched Oils
• Inhibition of Protein Phosphorylation in Macrophages by Antioxidants
• Water-soluble Antioxidants Inhibit Macrophage Recognition of Oxidized Erythrocytes
• Enhanced Adhesion of Oxidized Mouse Polymorphonuclear Leukocytes to Macrophages by a Cell-Surface Sugar-Dependent Mechanism
• Formation of Hydroxyfuranone and Hydroxypyranone Derivatives with DNA-Breaking Activity in the Maillard Reaction of Glucose and Albumin under Physiological Conditions
• Strategy in a Living Body to Protect against Oxidative Stress-Induced Damage
• Blue Fluorescence Generated during Lipid Oxidation of Rat Liver Microsomes Cannot Be Derived from Malonaldehyde but Can Be from Other Aldehyde Species
• Mutagenicity of Cooked Hamburger is Reduced by Addition of Ascorbate and Erythorbate to Ground Beef
• Effect of Plant Phenolics on the Formation of the Spin-Adduct of Hydroxyl Radical and the DNA Strand Breaking by Hydroxyl Radical
• Identification of the Cleavage Sites of Oxidized Protein That Are Susceptible to Oxidized Protein Hydrolase (OPH) in the Primary and Tertiary Structures of the Protein
• Effects of Oxygen on the Reactivity of Nitrogen Oxide Species Including Peroxynitrite(Biochemistry/Molecular Biology)
• Is Nitric Oxide (NO) an Antioxidant or a Prooxidant for Lipid Peroxidation?
• Suppression of Free Radical-Induced DNA Strand Breaks by Linoleic Acid and Low Density Lipoprotein in Vitro(Toxicology)
• Presence of Oxidized Protein Hydrolase in Human Cell Lines, Rat Tissues, and Human/Rat Plasma^1
• Purification and Characterization of a Serine Protease in Erythrocyte Cytosol That Is Adherent to Oxidized Membraanes and Preferentially Degrades Proteins Modified by Oxidation and Glycation
• Macrophage Binding and the Uptake of Oxidized Low Density Lipoprotein Are Regulated by Intracellular Protein Phosphorylation
• Enzymatic Removal of Oxidized Protein Aggregates from Erythrocyte Membranes
• Is Nitrotyrosine Generated in Human Erythrocytes in Circulation?
• Increased Band 3 Protein Aggregation and Anti-band 3 Binding of Erythrocyte Membranes on Treatment with Sesamol
• Binding of Anti-Band 3 Autoantibody to Sialylated Poly-N-Acetyllactosaminyl sugan Chains of Band 3 Glycoprotein on Eviednce for Anti-Band 3 Autoantibody Binding to the Sugar Chains of Oxidized and Senescent Erythrocytes
• Are Water-Soluble Natural Antioxidants Synergistic in Combination with α-Tocopherol?
• Fragrant 4-Hydroxy-3(2H)-furanones Swiftly Scavenge Nitrous Acid Causing Concomitant Formation of the Components with Relatively Weak Mutagenicity
• Vitamin E at Physiological Levels Enhances Mouse Macrophages to Bind and Incorporate Oxidized Low Density Lipoprotein
• Mouse Liver Microsomal Lipid Peroxidation and Antioxidant Effect of α-Tocopherol at the Low Oxygen Concentration
• Effects of Vitamin E-Deficiency and/or Nitrogen Dioxide Inhalation on Allergen-Sensitized Type IV and Type I Allergy Responses of Mice
• Low Inhibitory Activities of Food Phenolics Against Binding of Estradiol to Human Estrogen Receptor α
• Generation of Hydrogen Peroxide from Hydroxyhydroquinone and Its Inhibition by Superoxide Dismutase
• Increased Urinary Hydrogen Peroxide Levels Caused by Coffee Drinking
• Effect of Vitamin E on Contact Sensitization Responses Induced by 2, 4-Dinitrochlorobenzene in Mice

もっと見る 閉じる

スポンサーリンク