Generation of Hydrogen Peroxide from Hydroxyhydroquinone and Its Inhibition by Superoxide Dismutase
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概要
- 論文の詳細を見る
Hydroxyhydroquinone (HHQ) (1,2,4-benzenetriol), one of the metabolites of benzene and a component in roasted coffee beans, generated a 0.5-0.6 equimolar amount of hydrogen peroxide in a neutral solution by consuming dissolved oxygen. The consumption of dissolved oxygen and production of hydrogen peroxide by HHQ were greater than those by pyrogallol (1,2,3-benzenetriol), and much greater than those by hydroquinone and chlorogenic acid. Consumption of dissolved oxygen and generation of hydrogen peroxide by HHQ, and decomposition of HHQ were completely inhibited by Cu, Zn-, Mn- and Fe-superoxide dismutase (SOD). HHQ generated the semiquinone radical(s) as assessed by electron spin resonance studies, and also the colored quinoid forms of HHQ as assessed by colorimetry. SOD also inhibited the formation of the semiquinone radical(s) and the quinoid forms of HHQ. The results indicate that superoxide plays an important role as a catalyst in the generation of hydrogen peroxide from HHQ in a neutral solution.
- 日本油化学会の論文
- 2001-01-01
著者
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菊川 清見
東薬大・薬・衛生化学
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Hiramoto K
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Hiramoto Kazuyuki
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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菊川 清見
東京薬科大学薬学部
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Kikugawa Kiyomi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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MOCHIZUKI Ryo
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Mochizuki R
Waseda Univ. Tokyo Jpn
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Mochizuki Ryo
Laboratory Of Molecular Biology Department Of Molecular And Cell Biology Division Of Life Science Gr
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