Effects of Vitamin E-Deficiency and/or Nitrogen Dioxide Inhalation on Allergen-Sensitized Type IV and Type I Allergy Responses of Mice

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Effect of oxidative stress induced by vitamin E-deficiency and/or nitrogen dioxide (NO_2) inhalation on Type IV and Type I allergy responses of mice was investigated. Mice were fed a vitamin E-adequate diet (control : C group) or a vitamin E-deficient diet (-E group). The vitamin E content in the blood of C and -E groups was 1.58 and 0.3 μg/ ml, respectively. Mice of the C and -E groups were exposed to air or air containing NO_2 (5-6 ppm) (C + NO_2 and -E + NO_2 groups) by feeding them the corresponding diets for 1 -2 week. In the sensitization with 2,4-dinitrochlorobenzene (DNCB), the degree of lymph node cell proliferation of mice of the C + NO_2 group, as assessed by lymph node assay, was similar to that of mice of the C group. While the degree of cell proliferation of mice of the -E group was lower than that of mice of the C group, the degree of cell proliferation of mice of the -E + NO_2 group was higher than that of mice of the C and C + NO_2 groups. While the DNCB-sensitized IgE levels of mice of the C + NO_2 group were similar to those of mice of the C group, the IgE levels of mice of the -E and -E + NO_2 groups were higher than those of the C and C + NO_2 groups. While the trimellitic anhydride (TMA)-sensitized IgE levels of mice of the -E group were similar to those of mice of the C group, the IgE levels of mice of the C + NO_2 and -E + NO_2 groups were much higher. These results suggest that allergen-sensitized type IV and I allergy responses of mice are enhanced by oxidative stress induced by vitamin E-deficiency and/or NO_2 inhalation.
公益社団法人日本薬学会の論文
2002-02-01

Effects of Vitamin E-Deficiency and/or Nitrogen Dioxide Inhalation on Allergen-Sensitized Type IV and Type I Allergy Responses of Mice

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