^<32>P-Postlabeling Detection of DNA Base Adducts in Mice Induced by 4-(Hydroxymethyl) benzenediazonium Salt, a Carcinogen in Mushroom Agaricus bisporus
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概要
- 論文の詳細を見る
4-(Hydroxymethyl) benzenediazonium salt (HMBD), an ingredient in the edible mushroom Agaricus bisporus, is carcinogenic to mice and mutagenic to bacteria. Formation of carbon-centered radical from HMBD which induces DNA single strand breaks and modifies guanine and adenine moieties of DNA into 8-[4-(hydroxymethyl) phenyl] guanine and 8-[4-(hydroxy methyl) phenyl] adenine has been shown. In the present study HMBD was intraperitoneally administered to mice and in vivo formation of DNA base adducts in liver DNA was investigated by ^<32>P-postlabeling assay. A radioactive spot caused by the modified bases was observed in liver DNA 24 h after the administration which disappeared after 48 h. The base adduct formation may play a role in carcinogenesis of HMBD in mice.
- 公益社団法人日本薬学会の論文
- 1998-08-31
著者
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菊川 清見
東薬大・薬・衛生化学
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平本 一幸
東京薬大・薬
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加藤 哲太
東京薬科大学薬学部
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加藤 哲太
東京薬科大学薬学部薬学科
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平本 一幸
東京薬科大学薬学部
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平本 一幸
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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嘉久 雅恵
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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加藤 哲太
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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菊川 清見
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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嘉久 雅恵
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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