C-Nitrosation of Sesamol and Its Effects on N-Nitrosamine Formation in Vitro

概要

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Sesamol (II), a monophenolic antioxidant present in sesame oil, was found to interact readily with nitrite. In dilute aqueous solutions with II in excess, it rapidly and completely removed nitrite to produce an equivalent amount of 3,4-methylenedioxy-6-nitrosophenol (III) ; the rate was fastest at pH 2.0,followed by pH 3.0 and 4.0 in that order. In dilute solutions with nitrite in excess, the amount of III formed, which corresponded well to that of nitrite lost, was less than that of II initially present, and some side reactions may have occurred. Compound II either prevented the N-nitrosation of dimethylamine, as did pyrocatechol and L-ascorbic acid, or accelerated the reaction, depending upon the conditions. Compound III showed a catalytic effect on the N-nitrosation.
公益社団法人日本薬学会の論文
1979-10-25