Factors Influencing the Autoxidation of Hemoglobin A
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概要
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Autoxidation of hemoglobin A incubated at 20°or 37°over a period of 24 hr was affected by several factors. Oxidation of oxyhemoglobin (HbO_2) and deoxyhemoglobin (DeoxyHb) was faster as the pH value decreased. Allosteric effectors (IHP and EDTA) and reducing agents (ascorbic acid and cysteine) promoted the proton-assisted oxidation of HbO_2 to produce methemoglobin (MetHb) and/or precipitates. Metal ions (Fe^<2+>, Fe^<3+>, Cu^<2+> and Hg^<2+>) had a stimulatory effect at pH 7 and 5.5 on the production of MetHb or precipitates from both HbO_2 and DeoxyHb. The Cu^<2+>-and Hg^<2+>-catalyzed oxidations of HbO_2 were dramatically suppressed by EDTA, while those catalyzed by Fe^<2+> and Fe^<3+> were accelerated by EDTA. The Fe^<2+> (and Fe^<3+>)-EDTA complexes were potent inducers of the oxidation in the presence of oxygen, while EDTA blocked the Fe^<2+>-catalyzed oxidation of DeoxyHb. The oxidations catalyzed by all these metal ions were suppressed by ascorbic acid and cysteine. The Fe^<2+> (and Fe^<3+>)-ascorbate (and cysteine) complexes effectively deoxygenated HbO_2.
- 公益社団法人日本薬学会の論文
- 1981-05-23
著者
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菊川 清見
Tokyo College of Pharmacy
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呉地 伝夫
Tokyo College of Pharmacy
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呉地 伝夫
東京薬科大学
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笹原 富弥
Tokyo College of Pharmacy
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佐々木 武志
Tokyo College of Pharmacy
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