Interaction of Hemoglobin A with Sesamol and Polyphenolics
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The interactions of sesamol (I), a monophenolic antioxidant in sesame oil, pyrocatechol (II), p-hydroquinone (III) and pyrogallol (IV) with hemoglobin A were investigated. A large excess of the phenolic (I, II and III) induced methemoglobin (MetHb) formation from oxyhemoglobin (HbO_2) at pH 7 and 25°, the rates being in the order I>II>III. The diphenolics (II and III) also reduced MetHb to deoxyhemoglobin (DeoxyHb). Pyrogallol (IV) showed a more powerful ability to produce and reduce MetHb. Sesamol (I) readily produced MetHb from HbO_2 and even from DeoxyHb, but did not reduce MetHb. MetHb formation from HbO_2 by I prevailed in the acidic range. The amount of MetHb formed by I was characteristically proportional to the concentration of HbO_2,and more than 10 equivalents of MetHb was produced at high concentrations of HbO_2. MetHb formation by I, II and III from HbO_2 was enhanced by inositol hexaphosphate, whereas MetHb formation from DeoxyHb was inhibited. The mechanisms of action of the di-and triphenolics may involve electron transfer to HbO_2 and MetHb, but that of I could not be explained analogously.
- 公益社団法人日本薬学会の論文
- 1981-06-25
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