Fluorescence of 1,4-Dihydropyridine Derivatives Relevant to Age Pigments(Environmental,Chemical)
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1,4-Disubstituted-1,4-dihydropyridine-3,5-dicarbaldehydes, models of fluorogens in age pigments, show a high intensity of fluorescence comparable to that of quinine sulfate. Relationships between the structures and fluorescence emission of the 1,4-dihydropyridine derivatives were studied. Loss of substituents at the 1- or 4-positions had little effect on the fluorescence. Reduction of one of the aldehyde groups to an alcoholic group greatly decreased the fluorescence intensity. When the aldehyde groups were replaced by acetyl groups, the fluorescence was greatly decreased. A derivative without aldehyde or carbonyl groups at the 3 and 5-positions was virtually nonfluorescent. Thus, the aldehyde groups at the 3- and 5-positions are requisite for the high intensity of fluorescence of the 1,4-dihydropyridines.
- 公益社団法人日本薬学会の論文
- 1987-11-25
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