Inactivation of Mutagenic Heterocyclic and Aryl Amines by Linoleic Acid 13-Monohydroperoxide and Methemoglobin

概要

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The effect of the radical species generated by interaction of linoleic hydroperoxide (LOOH) with methemoglobin (MetHb) on the mutagenicity of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and 2-aminofluorene to Salmonella typhimurium TA98 was investigated. Treatment of Trp-P-1 and Trp-P-2 with LOOH alone gave rise to mutagenicity in the absence of S-9 mix but the extent was very low. Mutagenicity of Trp-P-1 and Trp-P-2 in the presence of S-9 mix was decreased by LOOH. Mutagenicity of 2-aminofluorene in the presence of S-9 mix was increased by LOOH, probably owing to the conversion of its active metabolite into more active form(s). Treatment of Trp-P-1,Trp-P-2 and 2-aminofluorene with the radical species generated-from LOOH-MetHb effectively decreased the level of the mutagens. The mutagenicity of the LOOH-MetHb-treated mutagens in the presence of S-9 mix was similarly retarded. The radical species effectively destroyed the mutagens by transforming them into non active form(s) that could not be activated by S-9 mix.
社団法人日本薬学会の論文
1988-12-25