Formation of Hydroxyfuranone and Hydroxypyranone Derivatives with DNA-Breaking Activity in the Maillard Reaction of Glucose and Albumin under Physiological Conditions
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概要
- 論文の詳細を見る
Formation of DNA breaking hydroxyfuranone and hydroxypyranone derivatives in the Maillard reaction of glucose and bovine serum albumin (BSA) under physiological conditions was investigated. A mixture of glucose and BSA was incubated at 37 ℃ in water or in 1 M phophate buffer (pH 7.4). The ethyl acetate/2-propanol extract of the reaction mixtures showed significant DNA breaking activity against supercoiled DNA especially in the presence of Fe(III) ion. Gas chromatography/mass spectrometry analysis of the mixture revealed the formation of DNA breaking hydroxyfuranones (HMF and DMHF) and hydroxypyranone (DDMP).
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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KIKUGAWA Kiyomi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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HIRAMOTO Kazuyuki
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Hiramoto Kazuyuki
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Kikugawa Kiyomi
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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ISHIHARA Akira
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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SAKUI Norihiro
Yokogawa Analytical Systems
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DAISHIMA Shigeki
Yokogawa Analytical Systems
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Ishihara A
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Hiramoto Kazuyoshi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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