酸化的ストレスによる損傷を受けた細胞に対する生体防御
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概要
- 論文の詳細を見る
The oxidative stress on cells causes modification of various cellular components such as proteins, lipids and nucleic acids, and leads to the damage of cell structure and function. The host defense system recognizes oxidatively damaged erythrocytes in two ways. One includes autoantibody to sialylated poly-N-acetyllactosaminyl carbohydrate chains of band 3 glycoprotein. The antibody binds to the oxidized cells by recognizing the carbohydrate chains on the cells. The antibody binding should lead to phagocytic removal of the oxidized cells from the circulation by macrophages. The other mechanism is direct recognition of the oxidized cells by macrophages through recognition of sialosaccharide chains of glycophorin A of the oxidized cells. These two mechanisms of recognition and removal of oxidatively damaged cells may be regarded as the secondary antioxidant defense at cellular level to maintain homeostasis of the body.
- 社団法人日本薬学会の論文
- 1994-08-31
著者
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別府 正敏
東京薬大 公衆衛生学
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別府 正敏
東京薬科大学
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別府 正敏
東京医科大学 小児科学
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菊川 清見
東京薬科大学薬学部第一衛生化学教室
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Beppu M
Tokyo College Of Pharmacy
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Beppu Masatoshi
School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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菊川 清見
東京薬科大学薬学部
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菊川 清見
東京薬科大学
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