Modifications of Nucleosides and Nucleotides. II. Reaction of Ethylene Oxide with 1-Methylcytosine
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概要
- 論文の詳細を見る
The reaction of aqueous ethylene oxide, a biologically important alkylating agent, with 1-methylcytosine (I) was investigated. At pH above 5,a hydroxyethylation was found to take place at N^3-position of I to yield 1-methyl-3-(2-hydroxyethyl)cytosine (II). When the pH of the reaction mixture was higher than 7,the reaction was followed by a further alkylation at the N^4-position of II to give 1-methyl-N, 3-bis(2-hydroxyethyl)-cytosine (III) and was also followed by hydrolysis of these products, II and III, to 1-methyl-3-(2-hydroxyethyl) uracil (IV). Mechanisms of these reactions are discussed in the light of reaction-rate differences at various pH's. At pH 14,II underwent Dimroth rearrangement to give 1-methyl-N-(2-hydroxyethyl)cytosine (V).
- 社団法人日本薬学会の論文
- 1964-10-25
著者
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水野 初彦
Faculty of Pharmaceutical Sciences, Osaka University
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奥山 治美
Faculty of Pharmaceutical Sciences, Nagoya City University
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奥山 治美
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences
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水野 初彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
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早津 彦哉
Faculty of Pharmaceutical Sciences, University of Tokyo
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浮田 忠之進
Faculty of Pharmaceutical Sciences, University of Tokyo
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早津 彦哉
Faculty Of Pharmaceutical Sciences Okayama University
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浮田 忠之進
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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早津 彦哉
Faculty of Pharmaceutical Sciences, Okayama University
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