Synergistic Action of Bisulfite and Dimethylsulfoxide on Bacteriophage Lambda
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概要
- 論文の詳細を見る
A synergistic action of sodium bisulfite and dimethylsulfoxide on bacteriophage lambda was found. A combination of 1M sodium bisulfite, pH5,and 3% dimethylsulfoxide showed a strong phage-inactivating effect, whereas 1M sodium bisulfite alone or 3% dimethylsulfoxide alone was without effect. It was shown that both bisulfite and dimethylsulfoxide must be present simultaneously in the incubation mixture to achieve the inactivation. The phages that had been treated with a mixture of bisulfite and dimethylsulfoxide were shown to have lost their ability to transfer the viral deoxyribonucleic acid (DNA) to the host bacteria. It was also observed that a DNA sample isolated from the treated phages was fully active in transfection assay. From these results, it was concluded that the target of the reagents was the coat protein of the phage.
- 公益社団法人日本薬学会の論文
- 1982-06-25
著者
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早津 彦哉
Faculty of Pharmaceutical Sciences, University of Tokyo
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早津 彦哉
Faculty Of Pharmaceutical Sciences Okayama University
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早津 彦哉
岡山大 薬 遺伝子実験施設
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根岸 和雄
Faculty of Pharmaceutical Sciences, Okayama University
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三吉 弘子(岩藤)
Faculty of Pharmaceutical Sciences, Okayama University
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永金 信子
Faculty of Pharmaceutical Sciences, Okayama University
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植前 磨理
Faculty of Pharmaceutical Sciences, Okayama University
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根岸 和雄
Okayama University Advanced Science Research Center:nihon Pharmaceutical University
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永金 信子
Faculty Of Pharmaceutical Sciences Okayama University
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三吉 弘子(岩藤)
Faculty Of Pharmaceutical Sciences Okayama University
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植前 磨理
Faculty Of Pharmaceutical Sciences Okayama University
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