シトシンアナログによる塩基の誤対合と変異

スポンサーリンク

概要

• 論文の詳細を見る

• We have found two highly mutagenic cytosine analogs, N^4-aminocytidine and P-nucleoside. Inside cells, these analogs are metabolized to the triphosphates, which can be incorporated into DNA by the replication machinery. Due to their ability to pair with guanine and adenine, they can induce replicational errors which would result in mutations. There seems to be two reasons for their high mutagenic potency. First, their efficient incorporation and low tautomeric constants cause high error rates in replication. Second, the analogs are retained in DNA because the cellular repair systems cannot remove these incorporated analogs efficiently.

• 日本環境変異原学会の論文
• 1998-10-31

著者

• 根岸 和雄

  Okayama University Advanced Science Research Center:nihon Pharmaceutical University

• 根岸 和雄

  岡山大学遺伝子実験施設

関連論文

• DNAの新しい抽出法 -キトサンを用いた方法-
• 変異原性ヌクレオチド, P-nucleoside triphosphateの鋳型-プライマーへの取り込み活性
• ヌクレオシドアナログによる塩基対合異常と突然変異 (核酸化学の新展開--新しい機能性分子を求めて) -- (核酸の構造)
• Synergistic Action of Bisulfite and Dimethylsulfoxide on Bacteriophage Lambda
• 防爆形冷蔵庫
• Formation of S-[5-(2'-Deoxyuridyl)] thiol Compounds in the Dehalogenation of 5-Bromo- and 5-Iodo-2'-deoxyuridine with Cysteine Derivatives
• Oxidative DNA Damage Induced by 364-nm UVA Laser in Yeast Cells
• シトシンアナログによる塩基の誤対合と変異
• DNAシークエンサーの選び方
• N^4-アミノシチジンによる突然変異の機構

スポンサーリンク