Oxidative DNA Damage Induced by 364-nm UVA Laser in Yeast Cells

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概要

• 論文の詳細を見る

• The mechanisms of the toxic effects of UVA (320-400nm) irradiation remain unclear. The actions of monochromatic longer wavelength UVA, in particular, have been difficult to analyze because of a lack of a powerful light source; however, a UVA laser that can be used for biological studies was recently developed. In the current studies, we examined the effects of 364-nm irradiation on yeast cells using a potent UVA laser. We found that, when irradiated under aerobic conditions, yeast cells lacking Ogg1 glycosylase were more sensitive than those with Ogg1. The ability of the 364-nm light to kill the yeast cells was almost eliminated by purging with argon gas. The mutagenic effects of the UVA irradiation did not appear to be enhanced by a lack of Ogg1. These results indicate the killing of yeast cells by 364-nm UVA may be dependent on oxidation and may involve DNA lesions that can be repaired by Ogg1.

• 日本環境変異原学会の論文
• 2006-05-31

著者

• Watanabe Masakatsu

  Okazaki National Research Institutes National Institute For Basic Biology

• 根岸 和雄

  Okayama University Advanced Science Research Center:nihon Pharmaceutical University

• Nakamura Takanori

  Okazaki National Research Institutes National Institute For Basic Biology

• Higashi Shoichi

  Okazaki National Research Institutes National Institute For Basic Biology

• Negishi Tomoe

  Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science

• Negishi Tomoe

  Graduate School Of Medicine Dentistry And Pharmaceutical Sciences

• Negishi Kazuo

  Okayama University Advanced Science Research Center

• Otsuka Chie

  Research Institute for Biological Sciences

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