Inhibitory Effects of Beer on Mutation in the Ames Test and DNA Adduct Formation in Mouse Organs Induced by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)(Pharmacology)
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概要
- 論文の詳細を見る
An evaluation of the antigenotoxic potential of beer components against carcinogens contained in the human diet, namely heterocyclic amines (HCAs) including 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP), was determined. The protective mechanism involved was also investigated. Beer samples were found to inhibit the mutagenicity of HCAs in the Ames test. Beer solution, consisting of a freeze-dried and dissolved sample, given as drink-water significantly reduced the formation of PhIP-DNA adducts in mouse colon and lung compared to control mice fed with PhIP in the absence of beer solution. Furthermore, beer solution added in the diet as a food additive mimic significantly reduced the amount of DNA adducts present in the liver and lung of mice fed with PhIP. In an effort to investigate the mechanism responsible for the observed protective effect, the effect of beer solutions on HCA metabolizing enzymes was investigated. Beer solutions inhibited the activity of CYP1A1 and CYP1A2, as determined from deethylation and demethylation assays using 7-ethoxy- and 7-methoxyresolufin, respectively. Considering the overall suppression of PhIP genotoxicity by beer, this study confirmed that beer components can interfere with the enzyme activity involved in the metabolism of HCAs and subsequently suppress the observed genotoxicity. The results of this study showed that beer components act in a protective capacity against the genotoxic effects of heterocyclic amines in vivo.
- 公益社団法人日本薬学会の論文
- 2006-01-01
著者
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Okamoto K
Department Of Microbiology Kyoto Pharmaceutical University
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Okamoto Kiyomi
Department Of Microbiology Kyoto Pharmaceutical University
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Okamoto Keinosuke
Faculty Of Pharmaceutical Sciences Okayama University
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Okamoto Keinosuke
Department Of Protein Function Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Oka
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Okamoto Keinosuke
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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Okamoto Keinosuke
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Ishida Rie
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Takahashi Eizo
Department Of Protein Function Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Oka
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Takahashi Eizo
Faculty Of Pharmaceutical Sciences Okayama University
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Takahashi Eizo
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Nakai Yumi
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Takata Jun
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Negishi Tomoe
Division Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Science
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Negishi Tomoe
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Negishi Tomoe
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Arimoto-kobayashi Sakae
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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IDEI Chiho
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Scien
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KONUMA Toshimitsu
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Scien
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Idei Chiho
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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Arimoto Sakae
Division Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Science
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Konuma Toshimitsu
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Division Of Pharmaceutical Science
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ARIMOTO Sakae
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Arimoto-kobayashi Sakae
Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Div. Of Pharmaceutical Sciences Ok
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