Studies on Fatty Acid Esters of Pyridoxine. VI. Effects of Surfaceactive Agents on the Gastro-intestinal Absorption of Pyridoxine 3,4-Dipalmitate in Man
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概要
- 論文の詳細を見る
Pyridoxine 3,4-dipalmitate (PIN-DP), insoluble in water, was little absorbed in man following oral administration of suspension in water or aqueous Tween 80. But, the absorption increased markedly with a solubilized solution with Tween 80. Previously, it was found that PIN-DP failed to permeate the intestinal tract unlike pyridoxine (PIN) which was the hydrolyzed product of ester in the tract. Hydrolysis of PIN-DP solubilized with Tween 80 increased ten times with the addition of sodium taurocholate or glycocholate. But, no increase was observed with the addition of sodium lauryl sulfate or bis (2-ethylhexyl) sulfosuccinate. PIN permeated through the everted sac of rat intestine following the addition of sodium taurocholate and lipase to a solubilized Tween 80 solution of PIN-DP.
- 社団法人日本薬学会の論文
- 1969-12-25
著者
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青木 大
Faculty Of Pharmaceutical Sciences Osaka University
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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矢田 登
Faculty of Pharmaceutical Sciences, Osaka University
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水野 初彦
Faculty of Pharmaceutical Sciences, Osaka University
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水野 初彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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