Release of Sodium Diclofenac from Vehicles Prepared with Hydrogenated Soya Lecithin and Methyl Palmitate

概要

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The release of sodium diclofenac (DC) from vehicles prepared with hydrogenated soya lecithin (lecithin) and methyl palmitate was remarkably sustained, was significantly influenced by each constituent in the vehicle. An increase of DC content as well as that of lecithin enhanced the release of DC. From these results, it is considered that the release of DC seems to be regulated by the infiltration rate of the dissolution medium. However, the release of DC during 24 h did not exceed 50% for all vehicles studied. This may be due to the poor solubility of lecithin in neutral water which is an important factor suppressing the infiltration of the medium into the matrix of the vehicle.To improve the release of DC, mannitol was incorporated into the matrix. As the content of mannitol was increased, the rate of drug release increased without disintegration of the spherical mass. Thus, release of DC from the vehicle can be easily controlled by adjusting the amount of mannitol incorporated into the vehicle.
社団法人日本薬学会の論文
1988-02-25