Determination of Pyrithioxin and Its Metabolites in Blood and Urine of Dogs by High-Performance Liquid Chromatography
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概要
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Analysis of pyrithioxin (I) and its metabolites in blood and urine by thin-layer chromatography and high-performance liquid chromatography was described following single oral doses of pyrithioxin dihydrochloride (I・2HCl) to beagle dogs. Pyrithioxin glucuronide (I-G), 5'-desoxy-5'-methylsulfinylpyridoxol (II) and its glucuronide (II-G) were found as metabolites in the urine. 5'-Desoxy-5'-methylthiopyridoxol (III), which was reported in the literature as one of main metabolites of I in the urine, was found to be a reduced product of II during the storage of excreted urine at room temperature. An analytical method of these metabolites in blood and urine was established employing a high-performance liquid chromatography with a cation-exchange resin column.
- 公益社団法人日本薬学会の論文
- 1977-06-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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矢田 登
Faculty of Pharmaceutical Sciences, Osaka University
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矢田 登
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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北尾 和彦
Faculty of Pharmaceutical Sciences, Osaka University
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北尾 和彦
Kyoto Pharmaceutical Industries Ltd.
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