Effect of Diethyl Maleate and Sodium Salicylate on Cefmetazole Transport in the in Vitro Rat Everted Intestinal Sac : Influence of Ca^<2+> and Vanadate in the Media(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
In Ca^<2+>-containing media, 1 mM diethyl maleate (DEM) increased the in vitro cefmetazole transport in rat everted colonic sac rapidly after a significant nonprotein thiol loss, but the increase in the ileal sac occurred only slowly after a significant nonprotein thiol loss. However, Ca^<2+>-free media promoted the adjuvant effect of DEM rapidly even in the ileal sac. Since vanadate in the Ca^<2+>-containing media also promoted the adjuvant effect of DEM, it is suggested that a perturbation of Ca^<2+> homeostasis as a secondary effect after nonprotein thioi loss is related to the increase of the intestinal mucosal permeability and that the ileal mucosa has stronger resistance to the secondary effect than the colonic mucosa does. The adjuvant effect of 300 mM salicylate (SA) was also promoted in Ca^<2+>-free media. Since the effect of SA was stronger than that of DEM even though SA caused less nonprotein thiol loss, it is considered that the effect of SA involves at least two mechanisms.
- 1987-04-25
著者
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鎌田 皎
Faculty Of Pharmaceutical Sciences Osaka University
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山崎 勝
Faculty of Pharmaceutical Sciences, Osaka University
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山崎 勝
大阪大学薬学部
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西畑 利明
大阪大学薬学部
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鈴鹿 卓美
Faculty of Pharmaceutical Sciences, Osaka University
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西畑 利明
Pharmacy Research Upjohn Tsukuba Research Laboratories
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西畑 利明
Faculty of Pharmaceutical Sciences, Osaka University
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鈴鹿 卓美
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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古屋 淳
Faculty of Pharmaceutical Sciences, Osaka University
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古屋 淳
Research Center Taisho Pharmaceutical Co. Ltd.
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