Effect of Water Extracts of Crude Drugs in Decreasing Blood Ethanol Concentrations in Rats(Pharmaceutical,Chemical)

スポンサーリンク

概要

• 論文の詳細を見る

• Oral administration of ethanol to rats at a dose of 3g/kg decreased the alcohol dehydrogenase (ADH) activity in liver cytosol. The effects of water extracts of eight crude drugs, which are believed to have protective activities against alcohol toxicity, on the blood ethanol concentration and on the ADH activity in liver cytosol were examined. Water extracts of these crude.drugs caused a rapid elimination of ethanol from the blood of normal rats when they were administered orally at 30 min before oral ethanol administration or simultaneously with ethanol. The rapid elimination of ethanol seems to be due to the effect of the water extracts in inhibiting the decrease of ADH activity in rat liver cytosol, and in supplementing nicotinamide adenine dinucleotide (a coenzyme in ethanol metabolism). Among the eight crude drugs, water extracts of only three crude drugs (Mori Albae Fructus, Alpiniae Katsumadai semen and Dolichoris semen) decreased the blood ethanol concentration and inhibited the decrease of ADH activity in liver cytosol when they were administered at 30 min after ethanol. Water extracts of the other crude drugs did not accelerate the ethanol elimination or inhibit the decrease of the ADH activity when administered 30 min after ethanol.

• 社団法人日本薬学会の論文
• 1987-11-25

著者

• 酒井 浄

  Faculty of Pharmaceutical Sciences, Kyushu University

• 酒井 浄

  Faculty Of Pharmaceutical Sciences Kyushu University

• 井川 智恵

  Osaka University Of Pharmaceutical Sciences

• 西畑 利明

  大阪大学薬学部

• 西畑 利明

  Pharmacy Research Upjohn Tsukuba Research Laboratories

• 酒井 浄

  Osaka University of Pharmaceutical Sciences

• 山根 敏子

  Osaka University of Pharmaceutical Sciences

• 斎藤 友希子

  Osaka University of Pharmaceutical Sciences

• 西畑 利明

  Faculty of Pharmaceutical Sciences, Osaka University

関連論文

• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• Enzymatic Hydrolysis of 2,2-Bis(acetoxymethyl)cycloalkanones, and Its Application to Formal Synthesis of (-)-Malyngolide
• Syntheses of Unsaturated Trihydroxy C-18 Fatty Acids Isolated from Rice Plants Suffering from Rice Blast Disease
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• サリチル酸ナトリウム,エチレンジアミン四酢酸ニナトリウム,及びポリオキシエチレン(23)ラウリルエーテルのセフォキシチンナトリウム直腸吸収促進効果の比較(発表論文抄録(1985年))
• エピネフリン代謝物によるセフメタゾール,セホキシチンのラット直腸吸収促進及びセファマイシン系抗生物質の高速液体クロマトグラフィーによる血中濃度の測定(発表論文抄録(1984年),福山大学開学10周年記念号)
• Synthetic Approach to 1,3-Polymethyl Function Based on Diastereoselective Conjugate Addition
• 82 ロジウム錯体を用いる高選択的不斉環化反応とイリドミルメシン類合成への応用(ポスター発表の部)
• 1 新規環変換反応の開発と二、三の天然物合成への応用(口頭発表の部)
• Diastereoselective Synthesis of Chiral 2,2,4-Trisubstituted 1,3-Dioxanes
• 74 Pseudomonas fluorescens lipaseの特性とキラルな生理活性化合物合成への応用(ポスター発表の部)
• Facile Synthesis of Furan Derivatives
• Silica Gel-Catalyzed Air Oxidation of Cyclopentenones
• Sultone Formation from α-Hydroxycyclopentanones and Alkanesulfonyl Chloride
• Formal Synthesis of dl-Plinol B
• 63(P1-11) 新規環拡大反応と(-)ムスコン合成への応用(ポスター発表の部)
• Practical Synthesis of Optically Active 6,6,Dichloro-2,2'-dipfenic Acid and Its Dimethyl Ester
• Preparation of Chiral, Highly Functionalized Cyclopentanes and Its Application to the Synthesis of Prostaglandin E_1
• Insight into the Cyclization of 6-Octen-1-als with Rhodium(I) Complex
• Diastereoselective Cyclization of 6-Octen-1-als with Rhodium(I)-Complex
• Preparation of Optically Active γ-Hydroxyethyl α, β-Unsaturated γ-Lactone Using an Enzymatic
• A Stereocontrolled Synthesis of Trisubstituted Cyclohexanes and Cyclopentanes. Its Application to the Synthesis of 11-Deoxyprostaglandins
• 76 キラルな多官能性シクロペンタンの合成と天然物合成への応用(口頭発表の部)
• Tetrodotoxin. VII. On the Structures of Tetrodotoxin and its Derivatives
• On the Structure of Tetrodotoxin
• Uber die Konstitution und Konfiguration des Anhydrotetrodotoxins
• Die Konstitution und Konfiguration der Tetrodonsaure
• 第18回薬物代謝と薬効・毒性シンポジウム
• Effect of Water Extracts of Crude Drugs in Decreasing Blood Ethanol Concentrations in Rats(Pharmaceutical,Chemical)
• 水素添加レシチンとMethyl Palmitateにより作成した基剤からのNa Diclofenacの放出(発表論文抄録(1988年))
• Preparation of Controlled-Release Granules of Sodium Diclofenac(Pharmaceutical)
• Use of High Performance Liquid Chromatography for Increased Assay Sensitivity of β-Lactamase Activity in Bile
• Influence of Diethyl Maleate-Induced Loss of Thiols on Cefmetazole Uptake into Isolated Epithelial Cells and on Cefmetazole Absorption from Ileal Loop of Rats(Pharmaceutical)
• Effect of Diethyl Maleate and Sodium Salicylate on Cefmetazole Transport in the in Vitro Rat Everted Intestinal Sac : Influence of Ca^ and Vanadate in the Media(Pharmaceutical)
• Application of Microorganisms and Enzymes to the Synthesis of Chiral Cyclopentane and Bicyclo[3.3.0]octane Derivatives(Organic,Chemical)
• Formation and Hydrolysis of Enamine in Aqueous Solution
• Effect of Extracts of Zingiberaceae Herbs on Gastric Secretion in Rabbits
• Effect of Water Extracts of Aloe and Some Herbs in Decreasing Bllod Ethanol Concentration in Rats. II.
• Glucose Release from Isolated, Perfused Liver of Alloxan-Diabetic Rats
• Intestinal Absorption of N, N'-Dimethylcarbamoylmethyl 4-(4-Guanidinobenzoyloxy) Phenylacetate Methanesulfonate in Rats
• Gas Chromatography of C_, C_, and C_ Sterols
• Use of Hydrogenated Soya Phospholipids as a Diluent : Preparation of Sustained-Release Tablets of Theophylline and Sodium Diclofenac(Pharmacological,Chemical)
• Enhancement of Rectal Absorption of Ampicillin by Sodium Salicylate in Rabbits
• Inhibitory Effect of Clindamycin on Production of β-Lactamase in β-Lactam-Resistant Bacteria
• Effect of 2,4-Dinitrophenol on Transport of Cefmetazole and Diclofenac from Thigh Muscle Tissue and from Intestinal Connective Tissue into Blood Circulation in Rats
• Inhibition of Gluconeogenesis by Salicylate and 5-Methoxysalicylate in Liver of Normal and Alloxan-Diabetic Rats(Pharmaceutical)
• Effect of Nonprotein Thiols in the Intestinal Tissue on the Transport of Salicylate
• Effect of Salicylate and Disodium Ethylenediaminetetraacetic Acid on the Rat Intestinal Absorption of Cefmetazole
• Enamine Formation of Various Amino Acids with Ethyl Acetoacetate in Aqueous Solution in Relation to Colonic Absorption of Cefmetazole
• Rectal Absorption of [Asu^]-Eel Calcitonin in Rats
• Rectal Absorption of Lysozyme and Heparin in Rabbits in the Presence of Non-surfactant Adjuvants
• Cefoxitinのラット小腸吸収に及ぼすTriglycerideの影響(発表論文抄録(1987年))
• ラットにおけるセフォキシチンナトリウムの腸管吸収 : 剤型の影響(発表論文抄録(1986年))
• Preparation of 2,6-Dioxabicyclo[3.3.0]octan-3,7-dione and Its Application to the Synthesis of (±)-Eldanolide
• Formal Syntheses of (-)-α- and (+)-β-Cuparenones, Cuparene, and Laurene
• Preparation of Chiral, Highly Functionalized Cyclopentenones
• A New Conversion Method from (-)-Limonene to Nepetalactones
• Enzymatic Procedure for the Synthesis of Prostaglandin A_2
• リモネンを原料とした生理活性物質の合成
• Asymmetric Synthesis of (+)-and (-)-Batyl Alcohol, a Key Synthetic Intermediate for Platelet-Activating Factor, by Using Biocatalysts(Organic,Chemical)
• Conversion of (+)-Limonen-10-ol to Bicyclo[3.3.0]octane Skeleton. Synthesis of a Key Intermediate for Carbacyclin(Organic,Chemical)
• Enzymatic Procedure for the Synthesis of 11-Deoxyprostaglandins(Organic,Chemical)
• Conversion of (-)-Limonen-10-ol to 11-Deoxyprostaglandin
• Novel Synthesis of Indan Derivatives
• 39 酵素化学的手法を用いたプロスタグランジンの合成
• Enzymatic Synthesis of 2,3-O-Isopropylidene-sn-glycerol, a Chiral Building Block for Platelet-Activating Factor
• USING MICROBIAL REDUCTION TO SYNTHESIZE CARBACYCLIN
• Simple Synthesis of trans-3,4-Bis(methoxycarbonylmethyl)cyclopentanone
• Conversion of Limonene to Prostanoic Acid and 8-Isoprostanoic Acid
• Formal Synthesis of Brefeldin A from (+)-Limonen-10-ol
• 15 リモネンを利用した光学活性シクロペンタノイドの合成
• Steroid Series. XVI. The Preparation of 3α, 5α-Cyclo-6β, 19-oxidosteroids and its Conversion to 19-Oxygenated Steroid Derivatives
• The Formation of 6,19-Epoxy-3,5-cyclo-steroid
• Untersuchungen uber Steroide. IX. Die Sterine aus Meeres-algen.
• Synthesis of 6a-Carbaprostaglandin I_3
• A Novel Synthesis of (±)-Carbacyclin
• Conversion of Methylenomycin A to Prostaglandin Analogues
• SYNTHESIS OF (±) 11-OXACARBACYCLIN
• Base-Catalyzed Reactions of Dihydromethylenomycin A and Its Derivatives
• A SYNTHESIS OF (±)-6,9α-METHANOPROSTAGLANDIN I_3,A STABLE ANALOG OF PROSTAGLANDIN I_3
• Isolation of 22-Dehydrocholesterol from Hypnea japonica
• Stereospecific Synthesis of Functionalized Cyclopentane Derivatives
• Syntheses of Some Branched-chain Nitrocycloalkanols
• PREPARATION OF A CHIRAL BUILDING BLOCK BASED ON 1,3-SYN-DIOL USING PSEUDOMONAS FLUORESCENSE LIPASE AND ITS APPLICATION TO THE SYNTHESIS OF A HUNGER MODULATOR
• Untersuchungen uber Steroide. XXXI. Umlagerung einer Doppelbindung an C_ der Sterin-Seitenkette bei Einwirkung von Jod.
• Untersuchungen uber Steroide. XXX. Versuche zur Synthese von Brassicasterin.
• Untersuchungen uber Steroide. XXIX. Versuche zur Synthese von Cholesta-7,22-dien-3β-ol.
• Untersuchungen uber Steroide. XXII. Versuche zur Synthese von 20-Iso-22-dehydrocholesterin.
• Untersuchungen uber Steroide. XX. Die Sterine aus grunen Meeres-Algen
• cis, cis-und trans, trans-1-Methyl-4-hydroxy-3,5-bis (athoxycarbonylmethyl) piperidin.
• The Synthesis of 9-Substituted p-Mentha-1,8 (10)-diene Derivatives
• SYNTHESIS OF CARBACYCLIN USING RHODIUM (I) COMPLEX
• SYNTHESIS BY MICROBIAL REDUCTION OF (S)-13-HYDROXY-9Z, 11E-OCTADECADIENOIC ACID, A DEFENSIVE SUBSTANCE IN RICE
• Synthetic Studies on Platelet-Activating Factor (PAF)

もっと見る 閉じる

スポンサーリンク