74 Pseudomonas fluorescens lipaseの特性とキラルな生理活性化合物合成への応用(ポスター発表の部)
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概要
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We have been studying the preparation of chiral synthons by using biocatalysts and its application for the synthesis of biologically active compounds. In its process, Pseudomonas fluorescens lipase (PFL) was found to possess high ability for discriminating between enantiomers of cyclic acetates ((dl)-1a-17a). In all cases, the R-acetates were predominantly hydrolyzed to afford 1b-17b. We have successfully proposed a novel stereomodel for R-preference in PFL-catalyzed hydrolysis. This stereochemical analysis is in good agreement with the experimental results among the tested 23 substrates. PFL was also found effective for asymmetric hydrolysis of meso-diacetates (21a, 31, and 34). By using PFL, we have succeeded for the syntheses of biologically active compounds such as carbacyclin, isocarbacyclin, a chiral butenolide (-)-26 for eldanolide and 11-deoxyprostaglandins, (-)-batyl alcohol for platelet activating factor (PAF), (-)-muscone, and hunger modulator (-)-36.
- 天然有機化合物討論会の論文
- 1990-09-25
著者
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九大・薬
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謝 卓峰
九大・薬
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酒井 浄
九大・薬
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末宗 洋
九州大学薬学部
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末宗 洋
九州大学大学院薬学府
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末宗 洋
九州大学大学院薬学研究院
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