リモネンを原料とした生理活性物質の合成
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Starting with (+) - and (-) -limonenes as chiral synthons, syntheses of biologically active compounds such as prostaglandins, (+) -brefeldin A and nepetalactones have been studied. The key-step of these conversions is based on the stereoselective cyclization of 3, 4-disubstituted 4-pentenals into <I>cis</I>-3, 4-disubstituted cyclopentanones using the Rh (I) -complex.<BR>Ring cleavage and reconstruction of five and six membered rings under acetalization conditions are also discussed.
- 社団法人 有機合成化学協会の論文
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