Application of Microorganisms and Enzymes to the Synthesis of Chiral Cyclopentane and Bicyclo[3.3.0]octane Derivatives(Organic,Chemical)
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概要
- 論文の詳細を見る
Optically active cyclopentane and bicyclo[3.3.0]octane derivatives were synthesized by utilizing biochemical methods. Pseudonlonas fluorescens lipase was found to be an effective enzyme for the enantioselective hydrolysis of monoacetoxy- and diacetoxycyclopentanes such as (±)-4a, (±)-5a, (±)-6a, and 7a. However, hydrolysis of bicyelo[3.3.0]octane trans-acetate ((±)-8a) using this enzyme resulted in low enantioselectivity. Optically pure (+)-8b for the synthesis of carbacyclin was obtained from (±)-8a by using porcine pancreatic lipase. Reduction of 3-acetyl-7-oxobicyelo[3.3.0]oct-2-ene with baker's yeast afforded a useful intermediate ((+)-11b) for the synthesis of hirsutic acid.
- 社団法人日本薬学会の論文
- 1987-11-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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謝 卓峰
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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謝 卓峰
九大・薬
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末宗 洋
九州大学薬学部
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中村 泉
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九州大学大学院薬学府
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末宗 洋
九州大学大学院薬学研究院
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