Steroid Series. XVI. The Preparation of 3α, 5α-Cyclo-6β, 19-oxidosteroids and its Conversion to 19-Oxygenated Steroid Derivatives
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概要
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3α, 5α-Cyclo-6β, 19-oxidosteroid (II) was synthesized by the lead tetraacetate oxidation of 3α, 5α-cyclo-6β-hydroxysteroid (I) in benzene. The acid-catalysed solvolysis of the oxide (II) afforded 3α, 5α-cyclo-19-hydroxy-6β-substituted steroid (XVI) and/or Δ^5-19-hydroxy-3β-substituted steroid (XVII), depending upon the reaction conditions employed. Oxidation of the oxide (II) with Jones reagent gave 3α, 5α-cyclo-6β, 19-dioxosteroid (XIX) with two equivalent molar oxidant, and 3α, 5α-cyclo-6-oxosteroid-19-oic acid (XX) with the excess reagent.
- 公益社団法人日本薬学会の論文
- 1967-01-25
著者
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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高崎 林治
Central Research Laboratories Sankyo Co. Ltd.
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酒井 浄
Central Research Laboratories, Sankyo Co., Ltd.
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林 了三
三共(株)分析代謝研究所
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林 了三
Central Research Laboratories, Sankyo Co., Ltd.
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森沢 靖弘
Central Research Laboratories Sankyo Co. Ltd.
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田部 克巳
Central Research Laboratories, Sankyo Co., Ltd.
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橋本 輝夫
Central Research Laboratories, Sankyo Co., Ltd.
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田辺 克巳
Central Research Laboratories Sankyo Co. Ltd.
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田部 克巳
Central Research Laboratories Sankyo Co. Ltd.
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橋本 輝夫
Central Research Laboratories Sankyo Co. Ltd.
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