Formal Synthesis of Brefeldin A from (+)-Limonen-10-ol
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概要
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The conversion of naturally abundant (+)-limonen-10-ol (2) into the synthetic intermediate (3) for brefeldin A is described. The cis-3,4-disubstituted cyclopentanone (4), which was easily obtained from 2 by Rh (I)-catalyzed cyclization reaction via the 4-pentenal derivative, could be converted to the target compound 3 via the appropriate modification of substituents on the five-membered ring.
- 公益社団法人日本薬学会の論文
- 1985-09-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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佐伯 清太郎
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
九州大学薬学部
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上野 貢嗣
Faculty Of Pharmaceutical Sciences Kyushu University
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佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九州大学大学院薬学研究院
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