Studies on Tertiary Amine Oxides. LXVI. Reactions of Quinoline 1-Oxide Derivatives with Tosyl Chloride in the Presence of Triethylamine
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概要
- 論文の詳細を見る
Reactions of N-oxides of lepidine (1a) and 4-methyl- (1b), 4-chloro- (1c) and 6-methoxyquinoline (1d) with tosyl chloride (1 eq) and triethylamine (ca. 10 eq) in a mixture of chloroform and water at room temperature gave the corresponding di (2-quinolyl) ethers (3a-d) and N-(2-quinolyl)-2-quinolones (4a-d). The efficiency of this type of reaction depends upon the nature and position of the substituents. Whereas the reaction of 1c with carbostyril under the same conditions gave small amounts of 4-chloro-2-tosyloxyquinoline (2c) and N-(4-chloro-2-quinolyl)-4-chloro-2-quinolone (4c), that of 1d afforded 6-methoxy-2-quinolyl 2'-quinolyl ether (15) and N-(6-methoxy-2-quinolyl)-2-quinolone (16) in 47 and 29% yields, respectively.
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
-
船越 和久
Faculty Of Pharmaceutical Sciences Kyushu University
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佐伯 清太郎
Faculty Of Pharmaceutical Sciences Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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七里 和子
Faculty Of Pharmaceutical Sciences Kyushu University
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